Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
Swit_3986PFAM: Glu/Leu/Phe/Val dehydrogenase, C terminal; Glu/Leu/Phe/Val dehydrogenase, dimerisation region; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (349 aa)    
Predicted Functional Partners:
Swit_0762
Transketolase domain protein; PFAM: dehydrogenase, E1 component; Transketolase, central region; Transketolase domain protein.
  
 
 0.967
Swit_3884
PFAM: dehydrogenase, E1 component; Transketolase, central region; Transketolase domain protein.
  
 
 0.967
Swit_0781
Branched-chain alpha-keto acid dehydrogenase E1 component; PFAM: Transketolase, central region; Transketolase domain protein.
  
 
 0.948
Swit_2144
Branched-chain alpha-keto acid dehydrogenase E1 component; PFAM: Transketolase, central region; Transketolase domain protein.
  
 
 0.948
Swit_0782
3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring); PFAM: dehydrogenase, E1 component.
  
 
 0.936
Swit_2145
PFAM: dehydrogenase, E1 component.
  
 
 0.936
Swit_0778
TIGRFAM: branched-chain amino acid aminotransferase; PFAM: aminotransferase, class IV.
  
 
 0.922
ilvE
Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.
  
 
 0.922
leuA
2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
  
 
 0.913
ilvD
PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; Belongs to the IlvD/Edd family.
   
 
 0.911
Your Current Organism:
Sphingomonas wittichii
NCBI taxonomy Id: 392499
Other names: S. wittichii RW1, Sphingomonas sp. RW1, Sphingomonas wittichii DSM 6014, Sphingomonas wittichii RW1, Sphingomonas wittichii str. RW1, Sphingomonas wittichii strain RW1
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.