Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Swit_4572PFAM: isochorismatase hydrolase. (212 aa)    
Predicted Functional Partners:
Swit_4571
Acetyltransferase-like protein.
  
    0.801
Swit_4570
PFAM: Pirin domain protein domain protein; Pirin domain protein; Belongs to the pirin family.
  
  
 0.776
Swit_4569
PFAM: NADPH-dependent FMN reductase.
     
 0.746
Swit_3610
Alpha,alpha-trehalose-phosphate synthase (UDP-forming); PFAM: glycosyl transferase, family 20.
  
    0.605
Swit_2810
TIGRFAM: flavoprotein WrbA; PFAM: NADPH-dependent FMN reductase; flavodoxin/nitric oxide synthase.
  
  
 0.553
Swit_2679
PFAM: protein of unknown function DUF1508.
   
  
 0.518
Swit_0736
PFAM: NAD/NADP octopine/nopaline dehydrogenase; NAD-dependent glycerol-3-phosphate dehydrogenase domain protein.
 
   0.504
Swit_0269
PFAM: Catalase domain protein.
  
 
 0.479
Swit_3730
PFAM: Catalase domain protein; Belongs to the catalase family.
  
 
 0.479
nnrD
Carbohydrate kinase, YjeF related protein; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow t [...]
  
    0.438
Your Current Organism:
Sphingomonas wittichii
NCBI taxonomy Id: 392499
Other names: S. wittichii RW1, Sphingomonas sp. RW1, Sphingomonas wittichii DSM 6014, Sphingomonas wittichii RW1, Sphingomonas wittichii str. RW1, Sphingomonas wittichii strain RW1
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