Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
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textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Score
Swit_4740Integral membrane sensor signal transduction histidine kinase; PFAM: ATP-binding region, ATPase domain protein domain protein; CHASE2 domain protein. (754 aa)    
Predicted Functional Partners:
Swit_4742
Two component transcriptional regulator, winged helix family; PFAM: response regulator receiver; transcriptional regulator domain protein.
 
 
 0.983
Swit_4741
PFAM: Peptidoglycan-binding LysM.
 
   
 0.955
Swit_2540
PFAM: response regulator receiver.
   
 
 0.881
Swit_1160
Multi-sensor hybrid histidine kinase; TIGRFAM: PAS sensor protein; PFAM: response regulator receiver; ATP-binding region, ATPase domain protein domain protein; histidine kinase A domain protein domain protein; CHASE3 domain protein; PAS fold domain protein; SMART: PAS domain containing protein.
 
 
0.856
Swit_4432
PAS/PAC sensor hybrid histidine kinase; TIGRFAM: PAS sensor protein; PFAM: response regulator receiver; ATP-binding region, ATPase domain protein domain protein; histidine kinase A domain protein domain protein; PAS fold-3 domain protein; PAS fold-4 domain protein; PAS fold domain protein; SMART: PAS domain containing protein; PAC repeat-containing protein.
 
 
 
 0.839
Swit_3187
PFAM: response regulator receiver.
 
 
 0.782
Swit_1954
Two component transcriptional regulator, winged helix family; PFAM: response regulator receiver; transcriptional regulator domain protein.
 
 
 0.779
Swit_3577
Two component transcriptional regulator, winged helix family; TIGRFAM: phosphate regulon transcriptional regulatory protein PhoB; PFAM: response regulator receiver; transcriptional regulator domain protein.
 
 
 0.778
Swit_2147
Two component transcriptional regulator, winged helix family; PFAM: response regulator receiver; transcriptional regulator domain protein.
 
 
 0.767
Swit_2781
PFAM: response regulator receiver.
 
 
 0.765
Your Current Organism:
Sphingomonas wittichii
NCBI taxonomy Id: 392499
Other names: S. wittichii RW1, Sphingomonas sp. RW1, Sphingomonas wittichii DSM 6014, Sphingomonas wittichii RW1, Sphingomonas wittichii str. RW1, Sphingomonas wittichii strain RW1
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