STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
nfuAIscR-regulated protein YhgI; Involved in iron-sulfur cluster biogenesis. Binds a 4Fe-4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S proteins. Could also act as a scaffold/chaperone for damaged Fe/S proteins. (192 aa)    
Predicted Functional Partners:
Swoo_0566
PFAM: aminotransferase class V; beta-lactamase domain protein; SMART: Rhodanese domain protein; KEGG: slo:Shew_3354 aminotransferase, class V.
  
 
 0.965
Swoo_1777
FeS cluster assembly scaffold IscU; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters.
  
 
 0.955
iscS
Cysteine desulfurase IscS; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.
  
 
 0.942
Swoo_0510
TIGRFAM: succinate dehydrogenase and fumarate reductase iron-sulfur protein; PFAM: ferredoxin; KEGG: sse:Ssed_4113 succinate dehydrogenase; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
  
 
 0.898
Swoo_1836
TIGRFAM: succinate dehydrogenase and fumarate reductase iron-sulfur protein; KEGG: sse:Ssed_2815 succinate dehydrogenase (ubiquinone); Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
  
 
 0.898
djlA
Heat shock protein DnaJ domain protein; Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB/RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host.
  
 
 0.859
hscB
Co-chaperone Hsc20; Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA; Belongs to the HscB family.
  
 
 0.859
Swoo_1136
PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; 4Fe-4S ferredoxin iron-sulfur binding domain protein; KEGG: sse:Ssed_1067 putative glutamate synthase (NADPH).
  
  
 0.845
Swoo_2160
TIGRFAM: glutaredoxin-like protein; PFAM: glutaredoxin; KEGG: sse:Ssed_2444 glutaredoxin-like protein; Belongs to the glutaredoxin family. Monothiol subfamily.
  
 0.828
Swoo_4816
PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; KEGG: sse:Ssed_4424 4Fe-4S ferredoxin, iron-sulfur binding domain protein.
  
  
 0.790
Your Current Organism:
Shewanella woodyi
NCBI taxonomy Id: 392500
Other names: S. woodyi ATCC 51908, Shewanella woodyi ATCC 51908, Shewanella woodyi str. ATCC 51908, Shewanella woodyi strain ATCC 51908
Server load: low (24%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.