| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Swoo_0484 | Swoo_4220 | Swoo_0484 | Swoo_4220 | PFAM: adenylate cyclase class-I; KEGG: sse:Ssed_4132 adenylate cyclase; Belongs to the adenylyl cyclase class-1 family. | KEGG: spl:Spea_3593 conserved hypothetical protein. | 0.401 |
| Swoo_0484 | lapA | Swoo_0484 | Swoo_2313 | PFAM: adenylate cyclase class-I; KEGG: sse:Ssed_4132 adenylate cyclase; Belongs to the adenylyl cyclase class-1 family. | Protein of unknown function DUF1049; Involved in the assembly of lipopolysaccharide (LPS). Belongs to the LapA family. | 0.739 |
| Swoo_0484 | slyX | Swoo_0484 | Swoo_0966 | PFAM: adenylate cyclase class-I; KEGG: sse:Ssed_4132 adenylate cyclase; Belongs to the adenylyl cyclase class-1 family. | PFAM: SlyX family protein; KEGG: sse:Ssed_0916 SlyX family protein; Belongs to the SlyX family. | 0.648 |
| Swoo_0484 | yihI | Swoo_0484 | Swoo_0055 | PFAM: adenylate cyclase class-I; KEGG: sse:Ssed_4132 adenylate cyclase; Belongs to the adenylyl cyclase class-1 family. | Protein of unknown function DUF414; A GTPase-activating protein (GAP) that modifies Der/EngA GTPase function. May play a role in ribosome biogenesis. Belongs to the YihI family. | 0.611 |
| Swoo_0967 | slyX | Swoo_0967 | Swoo_0966 | PFAM: WD-40 repeat protein; KEGG: sse:Ssed_0917 WD-40 repeat protein. | PFAM: SlyX family protein; KEGG: sse:Ssed_0916 SlyX family protein; Belongs to the SlyX family. | 0.800 |
| Swoo_1223 | Swoo_1238 | Swoo_1223 | Swoo_1238 | PFAM: Hpt domain protein; KEGG: sse:Ssed_1128 Hpt protein. | Anti sigma-E protein, RseA; An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish [...] | 0.694 |
| Swoo_1223 | Swoo_2885 | Swoo_1223 | Swoo_2885 | PFAM: Hpt domain protein; KEGG: sse:Ssed_1128 Hpt protein. | PFAM: protein of unknown function DUF412; KEGG: sse:Ssed_1706 protein of unknown function DUF412. | 0.770 |
| Swoo_1223 | Swoo_4220 | Swoo_1223 | Swoo_4220 | PFAM: Hpt domain protein; KEGG: sse:Ssed_1128 Hpt protein. | KEGG: spl:Spea_3593 conserved hypothetical protein. | 0.740 |
| Swoo_1223 | lapA | Swoo_1223 | Swoo_2313 | PFAM: Hpt domain protein; KEGG: sse:Ssed_1128 Hpt protein. | Protein of unknown function DUF1049; Involved in the assembly of lipopolysaccharide (LPS). Belongs to the LapA family. | 0.743 |
| Swoo_1223 | proQ | Swoo_1223 | Swoo_2132 | PFAM: Hpt domain protein; KEGG: sse:Ssed_1128 Hpt protein. | ProQ activator of osmoprotectant transporter ProP; RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities; Belongs to the ProQ family. | 0.687 |
| Swoo_1223 | rraB | Swoo_1223 | Swoo_4330 | PFAM: Hpt domain protein; KEGG: sse:Ssed_1128 Hpt protein. | Protein of unknown function DUF1260; Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. | 0.766 |
| Swoo_1223 | slyX | Swoo_1223 | Swoo_0966 | PFAM: Hpt domain protein; KEGG: sse:Ssed_1128 Hpt protein. | PFAM: SlyX family protein; KEGG: sse:Ssed_0916 SlyX family protein; Belongs to the SlyX family. | 0.735 |
| Swoo_1223 | yihI | Swoo_1223 | Swoo_0055 | PFAM: Hpt domain protein; KEGG: sse:Ssed_1128 Hpt protein. | Protein of unknown function DUF414; A GTPase-activating protein (GAP) that modifies Der/EngA GTPase function. May play a role in ribosome biogenesis. Belongs to the YihI family. | 0.742 |
| Swoo_1238 | Swoo_1223 | Swoo_1238 | Swoo_1223 | Anti sigma-E protein, RseA; An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish [...] | PFAM: Hpt domain protein; KEGG: sse:Ssed_1128 Hpt protein. | 0.694 |
| Swoo_1238 | Swoo_2885 | Swoo_1238 | Swoo_2885 | Anti sigma-E protein, RseA; An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish [...] | PFAM: protein of unknown function DUF412; KEGG: sse:Ssed_1706 protein of unknown function DUF412. | 0.717 |
| Swoo_1238 | lapA | Swoo_1238 | Swoo_2313 | Anti sigma-E protein, RseA; An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish [...] | Protein of unknown function DUF1049; Involved in the assembly of lipopolysaccharide (LPS). Belongs to the LapA family. | 0.584 |
| Swoo_1238 | proQ | Swoo_1238 | Swoo_2132 | Anti sigma-E protein, RseA; An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish [...] | ProQ activator of osmoprotectant transporter ProP; RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities; Belongs to the ProQ family. | 0.703 |
| Swoo_1238 | rraB | Swoo_1238 | Swoo_4330 | Anti sigma-E protein, RseA; An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish [...] | Protein of unknown function DUF1260; Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. | 0.747 |
| Swoo_1238 | slyX | Swoo_1238 | Swoo_0966 | Anti sigma-E protein, RseA; An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish [...] | PFAM: SlyX family protein; KEGG: sse:Ssed_0916 SlyX family protein; Belongs to the SlyX family. | 0.649 |
| Swoo_1238 | yihI | Swoo_1238 | Swoo_0055 | Anti sigma-E protein, RseA; An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish [...] | Protein of unknown function DUF414; A GTPase-activating protein (GAP) that modifies Der/EngA GTPase function. May play a role in ribosome biogenesis. Belongs to the YihI family. | 0.670 |