node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Swoo_3544 | Swoo_4751 | Swoo_3544 | Swoo_4751 | KEGG: sse:Ssed_3373 phosphoserine phosphatase; TIGRFAM: phosphoserine phosphatase SerB; HAD-superfamily hydrolase, subfamily IB (PSPase-like); PFAM: Haloacid dehalogenase domain protein hydrolase. | PFAM: aminotransferase class I and II; KEGG: spl:Spea_3654 aminotransferase class I and II. | 0.551 |
Swoo_3544 | hisA | Swoo_3544 | Swoo_2087 | KEGG: sse:Ssed_3373 phosphoserine phosphatase; TIGRFAM: phosphoserine phosphatase SerB; HAD-superfamily hydrolase, subfamily IB (PSPase-like); PFAM: Haloacid dehalogenase domain protein hydrolase. | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: sse:Ssed_2546 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | 0.764 |
Swoo_3544 | hisB | Swoo_3544 | Swoo_2089 | KEGG: sse:Ssed_3373 phosphoserine phosphatase; TIGRFAM: phosphoserine phosphatase SerB; HAD-superfamily hydrolase, subfamily IB (PSPase-like); PFAM: Haloacid dehalogenase domain protein hydrolase. | KEGG: spl:Spea_2459 histidinol-phosphatase; TIGRFAM: histidinol-phosphatase; histidinol-phosphate phosphatase family protein; hydrolase, HAD-superfamily, subfamily IIIA; PFAM: imidazoleglycerol-phosphate dehydratase; In the N-terminal section; belongs to the histidinol- phosphatase family. | 0.825 |
Swoo_3544 | hisC | Swoo_3544 | Swoo_2090 | KEGG: sse:Ssed_3373 phosphoserine phosphatase; TIGRFAM: phosphoserine phosphatase SerB; HAD-superfamily hydrolase, subfamily IB (PSPase-like); PFAM: Haloacid dehalogenase domain protein hydrolase. | TIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase class I and II; KEGG: sse:Ssed_2543 histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.551 |
Swoo_3544 | hisD | Swoo_3544 | Swoo_2091 | KEGG: sse:Ssed_3373 phosphoserine phosphatase; TIGRFAM: phosphoserine phosphatase SerB; HAD-superfamily hydrolase, subfamily IB (PSPase-like); PFAM: Haloacid dehalogenase domain protein hydrolase. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.686 |
Swoo_3544 | hisF | Swoo_3544 | Swoo_2082 | KEGG: sse:Ssed_3373 phosphoserine phosphatase; TIGRFAM: phosphoserine phosphatase SerB; HAD-superfamily hydrolase, subfamily IB (PSPase-like); PFAM: Haloacid dehalogenase domain protein hydrolase. | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.877 |
Swoo_3544 | hisG | Swoo_3544 | Swoo_2092 | KEGG: sse:Ssed_3373 phosphoserine phosphatase; TIGRFAM: phosphoserine phosphatase SerB; HAD-superfamily hydrolase, subfamily IB (PSPase-like); PFAM: Haloacid dehalogenase domain protein hydrolase. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.569 |
Swoo_3544 | hisH | Swoo_3544 | Swoo_2088 | KEGG: sse:Ssed_3373 phosphoserine phosphatase; TIGRFAM: phosphoserine phosphatase SerB; HAD-superfamily hydrolase, subfamily IB (PSPase-like); PFAM: Haloacid dehalogenase domain protein hydrolase. | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.771 |
Swoo_3544 | hisI | Swoo_3544 | Swoo_2081 | KEGG: sse:Ssed_3373 phosphoserine phosphatase; TIGRFAM: phosphoserine phosphatase SerB; HAD-superfamily hydrolase, subfamily IB (PSPase-like); PFAM: Haloacid dehalogenase domain protein hydrolase. | TIGRFAM: phosphoribosyl-ATP diphosphatase; PFAM: phosphoribosyl-AMP cyclohydrolase; phosphoribosyl-ATP pyrophosphohydrolase; KEGG: sse:Ssed_2548 phosphoribosyl-AMP cyclohydrolase; In the N-terminal section; belongs to the PRA-CH family. | 0.953 |
Swoo_4751 | Swoo_3544 | Swoo_4751 | Swoo_3544 | PFAM: aminotransferase class I and II; KEGG: spl:Spea_3654 aminotransferase class I and II. | KEGG: sse:Ssed_3373 phosphoserine phosphatase; TIGRFAM: phosphoserine phosphatase SerB; HAD-superfamily hydrolase, subfamily IB (PSPase-like); PFAM: Haloacid dehalogenase domain protein hydrolase. | 0.551 |
Swoo_4751 | hisA | Swoo_4751 | Swoo_2087 | PFAM: aminotransferase class I and II; KEGG: spl:Spea_3654 aminotransferase class I and II. | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: sse:Ssed_2546 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | 0.906 |
Swoo_4751 | hisB | Swoo_4751 | Swoo_2089 | PFAM: aminotransferase class I and II; KEGG: spl:Spea_3654 aminotransferase class I and II. | KEGG: spl:Spea_2459 histidinol-phosphatase; TIGRFAM: histidinol-phosphatase; histidinol-phosphate phosphatase family protein; hydrolase, HAD-superfamily, subfamily IIIA; PFAM: imidazoleglycerol-phosphate dehydratase; In the N-terminal section; belongs to the histidinol- phosphatase family. | 0.998 |
Swoo_4751 | hisC | Swoo_4751 | Swoo_2090 | PFAM: aminotransferase class I and II; KEGG: spl:Spea_3654 aminotransferase class I and II. | TIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase class I and II; KEGG: sse:Ssed_2543 histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.923 |
Swoo_4751 | hisD | Swoo_4751 | Swoo_2091 | PFAM: aminotransferase class I and II; KEGG: spl:Spea_3654 aminotransferase class I and II. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.968 |
Swoo_4751 | hisF | Swoo_4751 | Swoo_2082 | PFAM: aminotransferase class I and II; KEGG: spl:Spea_3654 aminotransferase class I and II. | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.928 |
Swoo_4751 | hisG | Swoo_4751 | Swoo_2092 | PFAM: aminotransferase class I and II; KEGG: spl:Spea_3654 aminotransferase class I and II. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.903 |
Swoo_4751 | hisH | Swoo_4751 | Swoo_2088 | PFAM: aminotransferase class I and II; KEGG: spl:Spea_3654 aminotransferase class I and II. | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.923 |
Swoo_4751 | hisI | Swoo_4751 | Swoo_2081 | PFAM: aminotransferase class I and II; KEGG: spl:Spea_3654 aminotransferase class I and II. | TIGRFAM: phosphoribosyl-ATP diphosphatase; PFAM: phosphoribosyl-AMP cyclohydrolase; phosphoribosyl-ATP pyrophosphohydrolase; KEGG: sse:Ssed_2548 phosphoribosyl-AMP cyclohydrolase; In the N-terminal section; belongs to the PRA-CH family. | 0.979 |
guaA | hisA | Swoo_1560 | Swoo_2087 | GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: sse:Ssed_2546 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | 0.783 |
guaA | hisB | Swoo_1560 | Swoo_2089 | GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. | KEGG: spl:Spea_2459 histidinol-phosphatase; TIGRFAM: histidinol-phosphatase; histidinol-phosphate phosphatase family protein; hydrolase, HAD-superfamily, subfamily IIIA; PFAM: imidazoleglycerol-phosphate dehydratase; In the N-terminal section; belongs to the histidinol- phosphatase family. | 0.404 |