Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
thiCThiamine biosynthesis protein ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. (652 aa)    
Predicted Functional Partners:
Swoo_2591
KEGG: sse:Ssed_2014 phosphomethylpyrimidine kinase, thiamine-phosphate diphosphorylase; TIGRFAM: thiamine-phosphate pyrophosphorylase; phosphomethylpyrimidine kinase; PFAM: thiamine monophosphate synthase; Phosphomethylpyrimidine kinase type-1.
 
 
 0.999
thiG
Thiazole biosynthesis family protein; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
 
  
 0.997
Swoo_2587
TIGRFAM: thiazole biosynthesis protein ThiH; PFAM: Radical SAM domain protein; biotin and thiamin synthesis associated; KEGG: sse:Ssed_2018 thiazole biosynthesis protein ThiH.
 
  
 0.991
Swoo_2589
TIGRFAM: thiamine biosynthesis protein ThiS; PFAM: thiamineS protein; KEGG: sse:Ssed_2016 thiamine biosynthesis protein ThiS.
  
  
 0.981
Swoo_2590
PFAM: UBA/THIF-type NAD/FAD binding protein; MoeZ/MoeB domain protein; KEGG: sse:Ssed_2015 UBA/ThiF-type NAD/FAD binding protein.
 
  
 0.929
purM
KEGG: sse:Ssed_1845 phosphoribosylformylglycinamidine cyclo-ligase; TIGRFAM: phosphoribosylformylglycinamidine cyclo-ligase; PFAM: AIR synthase related protein; AIR synthase related protein domain protein.
     
 0.807
purK
Phosphoribosylaminoimidazole carboxylase, ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
     
  0.800
Swoo_0138
KEGG: sse:Ssed_0158 hypothetical protein.
  
  
 0.724
Swoo_2740
KEGG: slo:Shew_1519 hypothetical protein.
  
  
 0.724
Swoo_4770
TIGRFAM: molybdopterin synthase sulfurylase MoeB; PFAM: UBA/THIF-type NAD/FAD binding protein; MoeZ/MoeB domain protein; KEGG: sse:Ssed_4378 molybdopterin synthase sulfurylase MoeB.
 
  
 0.702
Your Current Organism:
Shewanella woodyi
NCBI taxonomy Id: 392500
Other names: S. woodyi ATCC 51908, Shewanella woodyi ATCC 51908, Shewanella woodyi str. ATCC 51908, Shewanella woodyi strain ATCC 51908
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