node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Swoo_0624 | fhs | Swoo_0624 | Swoo_4339 | KEGG: sse:Ssed_4039 methylenetetrahydrofolate reductase (NAD(P)H); TIGRFAM: 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | PFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: sse:Ssed_0612 formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.444 |
Swoo_0624 | folD | Swoo_0624 | Swoo_3115 | KEGG: sse:Ssed_4039 methylenetetrahydrofolate reductase (NAD(P)H); TIGRFAM: 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Methylenetetrahydrofolate dehydrogenase (NADP(+)); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.940 |
Swoo_0624 | gcvT | Swoo_0624 | Swoo_3969 | KEGG: sse:Ssed_4039 methylenetetrahydrofolate reductase (NAD(P)H); TIGRFAM: 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.942 |
Swoo_0624 | glyA | Swoo_0624 | Swoo_1380 | KEGG: sse:Ssed_4039 methylenetetrahydrofolate reductase (NAD(P)H); TIGRFAM: 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.953 |
Swoo_0624 | purH | Swoo_0624 | Swoo_0296 | KEGG: sse:Ssed_4039 methylenetetrahydrofolate reductase (NAD(P)H); TIGRFAM: 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | KEGG: spl:Spea_0432 phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: MGS domain protein; AICARFT/IMPCHase bienzyme formylation region. | 0.405 |
Swoo_0624 | purN | Swoo_0624 | Swoo_2745 | KEGG: sse:Ssed_4039 methylenetetrahydrofolate reductase (NAD(P)H); TIGRFAM: 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.418 |
Swoo_0624 | thyA | Swoo_0624 | Swoo_1230 | KEGG: sse:Ssed_4039 methylenetetrahydrofolate reductase (NAD(P)H); TIGRFAM: 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.933 |
Swoo_3984 | folD | Swoo_3984 | Swoo_3115 | PFAM: 5-formyltetrahydrofolate cyclo-ligase; KEGG: spl:Spea_3311 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | Methylenetetrahydrofolate dehydrogenase (NADP(+)); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.949 |
Swoo_3984 | glyA | Swoo_3984 | Swoo_1380 | PFAM: 5-formyltetrahydrofolate cyclo-ligase; KEGG: spl:Spea_3311 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.448 |
Swoo_3984 | purN | Swoo_3984 | Swoo_2745 | PFAM: 5-formyltetrahydrofolate cyclo-ligase; KEGG: spl:Spea_3311 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.933 |
fhs | Swoo_0624 | Swoo_4339 | Swoo_0624 | PFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: sse:Ssed_0612 formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | KEGG: sse:Ssed_4039 methylenetetrahydrofolate reductase (NAD(P)H); TIGRFAM: 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.444 |
fhs | fmt | Swoo_4339 | Swoo_0037 | PFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: sse:Ssed_0612 formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.412 |
fhs | folD | Swoo_4339 | Swoo_3115 | PFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: sse:Ssed_0612 formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Methylenetetrahydrofolate dehydrogenase (NADP(+)); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.996 |
fhs | gcvT | Swoo_4339 | Swoo_3969 | PFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: sse:Ssed_0612 formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.953 |
fhs | glyA | Swoo_4339 | Swoo_1380 | PFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: sse:Ssed_0612 formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.972 |
fhs | purH | Swoo_4339 | Swoo_0296 | PFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: sse:Ssed_0612 formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | KEGG: spl:Spea_0432 phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: MGS domain protein; AICARFT/IMPCHase bienzyme formylation region. | 0.991 |
fhs | purN | Swoo_4339 | Swoo_2745 | PFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: sse:Ssed_0612 formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.968 |
fhs | purU | Swoo_4339 | Swoo_3286 | PFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: sse:Ssed_0612 formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). | 0.628 |
fhs | thyA | Swoo_4339 | Swoo_1230 | PFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: sse:Ssed_0612 formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.401 |
fmt | fhs | Swoo_0037 | Swoo_4339 | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | PFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: sse:Ssed_0612 formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.412 |