Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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gene co-occurrence
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queEOrganic radical activating enzyme; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. (208 aa)    
Predicted Functional Partners:
SKD01417.1
6-pyruvoyltetrahydropterin/6- carboxytetrahydropterin synthase.
 
 
 0.986
SKD08855.1
7-cyano-7-deazaguanine reductase.
  
 
 0.921
tgt
Queuine tRNA-ribosyltransferase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form t [...]
    
 0.743
dut
dUTP pyrophosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family.
    
  0.716
hemE
Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
     
  0.706
SKC97851.1
Protoporphyrinogen IX oxidase, menaquinone-dependent (flavodoxin domain).
     
  0.625
SKC99400.1
Acyl-protein synthetase, LuxE.
  
     0.609
folE
GTP cyclohydrolase I.
  
 
 0.593
SKD01348.1
WD40-like Beta Propeller Repeat.
       0.581
folD-2
Methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.
       0.579
Your Current Organism:
Chitinophaga ginsengisegetis
NCBI taxonomy Id: 393003
Other names: C. ginsengisegetis, Chitinophaga ginsengisegetis Lee et al. 2007, DSM 18108, KCTC 12654, strain Gsoil 040
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