STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Co-occurrence
Co-expression
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[Homology]
Score
hemF-2Coproporphyrinogen III oxidase, aerobic; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX. (302 aa)    
Predicted Functional Partners:
hemE
Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
 
 0.967
aroE
Shikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
 
  
 0.955
hemF
Coproporphyrinogen oxidase; Identified by match to TIGR protein family HMMTIGR00538 InterPro: Oxygen-independent coproporphyrinogen III oxidase HemN; High confidence in function and specificity; Belongs to the anaerobic coproporphyrinogen-III oxidase family.
    
 0.950
ABO_0357
Conserved hypothetical protein.
 
  
 0.939
tsaC
Sua5/YciO/YrdC/YwlC family protein; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate.
     
 0.750
ABO_0137
(conserved hypothetical protein, Kef-type K+ transport systems, predicted NAD-binding component) identified by sequencesimilarity; putative InterPro: Potassium channel; Family membership.
       0.746
hemH
Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family.
 
  
 0.684
ABO_0138
(Uncharacterized protein conserved in bacteria, COG3528).
       0.648
ABO_2599
Oxygenase; Family membership.
  
  
 0.583
dprA
(peptide deformylase)(smf family protein; DNA processing protein, DprA, putative) identified by sequence similarity; putative InterPro: SMF family; Family membership.
       0.570
Your Current Organism:
Alcanivorax borkumensis
NCBI taxonomy Id: 393595
Other names: A. borkumensis SK2, Alcanivorax borkumensis SK2, Alcanivorax borkumensis str. SK2, Alcanivorax borkumensis strain SK2
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