STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
pabAChorismate lyase, putative; Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4-hydroxybenzoate (4HB) for the ubiquinone pathway; Belongs to the UbiC family. (204 aa)    
Predicted Functional Partners:
ubiA
UbiA prenyltransferase; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate.
    
 0.975
ABO_0754
Conserved hypothetical protein TIGR00051, has high similarity with predicted thioesterases of COG0824.
    
 0.900
pheA
(P-protein including chorismate mutase and prephenate dehydratase) identified by sequence similarity; putative identified by match to PFAM protein family HMMPF01817 InterPro: Prephenate dehydratase (PDT); High confidence in function and specificity.
    
 0.870
tyrA/aroF
Prephenate dehydrogenase/3-phosphoshikimate 1-carboxyvinyltr; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
    
 0.848
hisC-1
(histidinol-phosphate aminotransferase, imidazole acetol-phosphate transaminase) identified by sequence similarity; putative identified by match to PFAM protein family HMMPF00155 InterPro: Aminotransferases class-I; High confidence in function and specificity; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
  
  
  0.829
trpE
Anthranilate synthase, component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concent [...]
    
 0.811
aroC
Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
     
 0.808
trpG
(anthranilate synthase component II, glutamine amidotransferase) identified by sequence similarity; putative identified by match to PFAM protein family HMMPF00117 and TIGRFAM protein family HMMTIGR00566; putative; High confidence in function and specificity.
    
 0.807
aspC
(aspartate aminotransferase, transaminase A) identified by sequence similarity; putative identified by match to PFAM protein family HMMPF00155 InterPro: Aminotransferases class-I; High confidence in function and specificity.
     
  0.800
hisC-2
(histidinol-phosphate aminotransferase, imidazole acetol-phosphate transaminase) identified by sequence similarity; putative identified by match to PFAM protein family HMMPF00155 InterPro: Aminotransferases class-I; High confidence in function and specificity; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
     
  0.800
Your Current Organism:
Alcanivorax borkumensis
NCBI taxonomy Id: 393595
Other names: A. borkumensis SK2, Alcanivorax borkumensis SK2, Alcanivorax borkumensis str. SK2, Alcanivorax borkumensis strain SK2
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