node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABO_0176 | gmk-2 | ABO_0176 | ABO_0178 | GTP pyrophosphokinase/Guanosine-3',5'-bis(Diphosphate) 3'-pyrophosphohydrolase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.943 |
ABO_0176 | ndk | ABO_0176 | ABO_1864 | GTP pyrophosphokinase/Guanosine-3',5'-bis(Diphosphate) 3'-pyrophosphohydrolase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. | Nucleoside-diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.911 |
ABO_0176 | nrdA | ABO_0176 | ABO_0711 | GTP pyrophosphokinase/Guanosine-3',5'-bis(Diphosphate) 3'-pyrophosphohydrolase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. | Ribonucleoside reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | 0.905 |
ABO_0176 | nrdB | ABO_0176 | ABO_0710 | GTP pyrophosphokinase/Guanosine-3',5'-bis(Diphosphate) 3'-pyrophosphohydrolase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. | Ribonucleoside reductase, beta subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. | 0.900 |
ABO_0176 | pykA | ABO_0176 | ABO_2621 | GTP pyrophosphokinase/Guanosine-3',5'-bis(Diphosphate) 3'-pyrophosphohydrolase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. | (pyruvate kinase) identified by sequencesimilarity; putative InterPro: Pyruvate kinase family; High confidence in function and specificity; Belongs to the pyruvate kinase family. | 0.918 |
ABO_0176 | rpoZ | ABO_0176 | ABO_0177 | GTP pyrophosphokinase/Guanosine-3',5'-bis(Diphosphate) 3'-pyrophosphohydrolase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. | DNA-directed RNA polymerase, omega subunit; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits. | 0.618 |
ABO_0278 | gmk-2 | ABO_0278 | ABO_0178 | Identified by match to PFAM protein family HMMPF00702 InterPro: Haloacid dehalogenase/epoxide hydrolase family; Family membership. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.900 |
ABO_0278 | guaA | ABO_0278 | ABO_0051 | Identified by match to PFAM protein family HMMPF00702 InterPro: Haloacid dehalogenase/epoxide hydrolase family; Family membership. | (glutamine amidotransferase class I) identified by match to TIGR protein family HMMTIGR00888; Family membership. | 0.901 |
ABO_0278 | guaA-2 | ABO_0278 | ABO_1850 | Identified by match to PFAM protein family HMMPF00702 InterPro: Haloacid dehalogenase/epoxide hydrolase family; Family membership. | GMP synthase (glutamine-hydrolysing); Catalyzes the synthesis of GMP from XMP. | 0.904 |
ABO_0278 | hpt | ABO_0278 | ABO_1020 | Identified by match to PFAM protein family HMMPF00702 InterPro: Haloacid dehalogenase/epoxide hydrolase family; Family membership. | Hypoxanthine phosphoribosyltransferase; Identified by sequence similarity; putative InterPro: Phosphoribosyl transferase; High confidence in function and specificity. | 0.900 |
gmk-2 | ABO_0176 | ABO_0178 | ABO_0176 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | GTP pyrophosphokinase/Guanosine-3',5'-bis(Diphosphate) 3'-pyrophosphohydrolase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. | 0.943 |
gmk-2 | ABO_0278 | ABO_0178 | ABO_0278 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Identified by match to PFAM protein family HMMPF00702 InterPro: Haloacid dehalogenase/epoxide hydrolase family; Family membership. | 0.900 |
gmk-2 | guaA | ABO_0178 | ABO_0051 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | (glutamine amidotransferase class I) identified by match to TIGR protein family HMMTIGR00888; Family membership. | 0.912 |
gmk-2 | guaA-2 | ABO_0178 | ABO_1850 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | GMP synthase (glutamine-hydrolysing); Catalyzes the synthesis of GMP from XMP. | 0.959 |
gmk-2 | hpt | ABO_0178 | ABO_1020 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Hypoxanthine phosphoribosyltransferase; Identified by sequence similarity; putative InterPro: Phosphoribosyl transferase; High confidence in function and specificity. | 0.938 |
gmk-2 | ndk | ABO_0178 | ABO_1864 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Nucleoside-diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.931 |
gmk-2 | nrdA | ABO_0178 | ABO_0711 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Ribonucleoside reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | 0.931 |
gmk-2 | nrdB | ABO_0178 | ABO_0710 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Ribonucleoside reductase, beta subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. | 0.904 |
gmk-2 | pykA | ABO_0178 | ABO_2621 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | (pyruvate kinase) identified by sequencesimilarity; putative InterPro: Pyruvate kinase family; High confidence in function and specificity; Belongs to the pyruvate kinase family. | 0.927 |
gmk-2 | rpoZ | ABO_0178 | ABO_0177 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | DNA-directed RNA polymerase, omega subunit; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits. | 0.933 |