STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
gmk-2Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. (207 aa)    
Predicted Functional Partners:
guaA-2
GMP synthase (glutamine-hydrolysing); Catalyzes the synthesis of GMP from XMP.
 
 
 0.963
ABO_0176
GTP pyrophosphokinase/Guanosine-3',5'-bis(Diphosphate) 3'-pyrophosphohydrolase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.
  
 
 0.946
hpt
Hypoxanthine phosphoribosyltransferase; Identified by sequence similarity; putative InterPro: Phosphoribosyl transferase; High confidence in function and specificity.
  
 
 0.933
ndk
Nucleoside-diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.
   
 0.924
purB
Adenylosuccinate lyase; purB identified by sequencesimilarity; putative InterPro: Adenylosuccinate lyase; High confidence in function and specificity; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
   
 0.922
guaA
(glutamine amidotransferase class I) identified by match to TIGR protein family HMMTIGR00888; Family membership.
  
 
 0.911
nrdA
Ribonucleoside reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
     
 0.911
ABO_0278
Identified by match to PFAM protein family HMMPF00702 InterPro: Haloacid dehalogenase/epoxide hydrolase family; Family membership.
     
  0.910
nrdB
Ribonucleoside reductase, beta subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family.
   
 
 0.905
ABO_1622
(MazG nucleotide pyrophosphohydrolase domain family protein) identified by match to TIGR protein family HMMTIGR00444 InterPro: MazG family protein; Function unclear.
     
 0.901
Your Current Organism:
Alcanivorax borkumensis
NCBI taxonomy Id: 393595
Other names: A. borkumensis SK2, Alcanivorax borkumensis SK2, Alcanivorax borkumensis str. SK2, Alcanivorax borkumensis strain SK2
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