Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
pfkB(carbohydrate kinase, PfkB family) identified by sequencesimilarity; putative; High confidence in function and specificity; Belongs to the carbohydrate kinase PfkB family. (334 aa)    
Predicted Functional Partners:
hisA
Phosphoribosylformimino-5-aminoimidazolecarboxam ide ribotide; (1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)met hylideneamino] imidazole-4-carboxamide isomerase, phosphoribosylformimino-5-aminoimidazolecarboxamide ribotide isomerase) identified by sequence similarity; putative identified by match to TIGRFAM protein family HMMTIGR00007 InterPro: Histidine biosynthesis protein; High confidence in function and specificity.
  
    0.731
lytB
LytB protein; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family.
      0.713
ABO_0349
(Rieske 2Fe-2S family protein) identified by match to PFAM protein family HMMPF00355 InterPro: Rieske iron-sulfur protein 2Fe-2S subunit; Function unclear.
  
  
 0.676
mrcB
Penicillin-binding protein; Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross- linking of the peptide subunits).
     
 0.646
ahcy
Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.
 
 
 0.611
gltX
glutamyl-tRNA synthetase-related protein; Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5-dihydroxy-2- cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon; Belongs to the class-I aminoacyl-tRNA synthetase family. GluQ subfamily.
  
 
 0.601
srkA
Conserved hypothetical protein; A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response.
       0.585
purA
Adenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.
  
 
 0.567
sodB
Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family.
    
 
 0.545
gltB
Glutamate synthase, large subunit; Identified by sequencesimilarity; putative identified by match to PFAM protein family HMMPF04897 and HMMPF01645 InterPro: Ferredoxin-dependent glutamate synthase; High confidence in function and specificity.
      
 0.461
Your Current Organism:
Alcanivorax borkumensis
NCBI taxonomy Id: 393595
Other names: A. borkumensis SK2, Alcanivorax borkumensis SK2, Alcanivorax borkumensis str. SK2, Alcanivorax borkumensis strain SK2
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