Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
birAbiotin-[acetyl-CoA-carboxylase] ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. (326 aa)    
Predicted Functional Partners:
bioB
Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family.
  
 
 0.965
coaX
Transcriptional activator, putative; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis; Belongs to the type III pantothenate kinase family.
  
    0.958
tadA
Cytidine/deoxycytidylate deaminase family protein; Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2); Belongs to the cytidine and deoxycytidylate deaminase family.
  
    0.909
ABO_1128
Conserved hypothetical protein; Identified by sequence similarity; putative InterPro: Glycoprotease (M22) metallo-protease family.
 
    0.892
accC
acetyl-CoA carboxylase, biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.
 
 0.891
fadD
(long-chain fatty-acid-CoA ligase putative) identified by match to TIGR protein family HMMTIGR01734 InterPro: AMP-dependent synthetase and ligase; High confidence in function and specificity.
  
  
 0.844
xthA
(xth), (Exonuclease III),(EXO III),(APendonuclease VI). identified by sequencesimilarity; putative InterPro: AP endonucleases family 1 Exodeoxyribonuclease III xth; High confidence in function and specificity.
  
    0.841
uahA
Urea carboxylase/allophanate hydrolase; Urea carboxylase; urease (ATP-hydrolysing); urea amidolyase/allophanate hydrolase [EC:6.3.4.6 3.5.1.54] identified by sequence similarity; putative InterPro: DUF183; Family membership.
 
  
 0.776
accC,
acetyl-CoA carboxylase, biotin carboxylase; Identified by match to TIGR protein family HMMTIGR00514 InterPro: Carbamoyl-phosphate synthase; High confidence in function and specificity.
 
  
 0.775
ABO_0370
Conserved hypothetical protein.
       0.765
Your Current Organism:
Alcanivorax borkumensis
NCBI taxonomy Id: 393595
Other names: A. borkumensis SK2, Alcanivorax borkumensis SK2, Alcanivorax borkumensis str. SK2, Alcanivorax borkumensis strain SK2
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