Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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ileSIsoleucyl-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily. (937 aa)    
Predicted Functional Partners:
proS
Prolyl-tRNA synthetase; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves dea [...]
   
 0.981
leuS
(isoleucyl-tRNA synthetase) identified by sequencesimilarity; putative InterPro: Leucyl-tRNA synthetase; High confidence in function and specificity; Belongs to the class-I aminoacyl-tRNA synthetase family.
 
0.971
metG
Methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
  
 0.967
argS
arginyl-tRNA synthetase; Identified by sequence similarity; putative; High confidence in function and specificity.
  
 0.960
ribF
FAD pyrophosphorylase; (riboflavin biosynthesis protein RibF) identified by sequence similarity; putative InterPro: Riboflavin kinase / FAD synthetase; High confidence in function and specificity; Belongs to the ribF family.
 
    0.936
lspA-2
Signal peptidase II; This protein specifically catalyzes the removal of signal peptides from prolipoproteins; Belongs to the peptidase A8 family.
  
 0.934
lysS
Lysyl-tRNA synthetase; Identified by sequencesimilarity; putative InterPro: Lysyl-tRNA synthetase class-2; High confidence in function and specificity; Belongs to the class-II aminoacyl-tRNA synthetase family.
 
 0.918
fkpB
Peptidyl-prolyl cis-trans isomerase FKBP-type identified by sequencesimilarity; putative InterPro: FKBP-type peptidyl-prolyl cis-trans isomerase (PPIase); Specificity unclear.
 
  
 0.907
pheT
Phenylalanyl-tRNA synthetase, beta subunit; Identified by sequence similarity; putative; High confidence in function and specificity; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
  
 
 0.895
murJ
Membrane protein, MviN family; Involved in peptidoglycan biosynthesis. Transports lipid- linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane.
     0.852
Your Current Organism:
Alcanivorax borkumensis
NCBI taxonomy Id: 393595
Other names: A. borkumensis SK2, Alcanivorax borkumensis SK2, Alcanivorax borkumensis str. SK2, Alcanivorax borkumensis strain SK2
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