Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
tdhTartrate dehydrogenase; Identified by sequence similarity; putative identified by match to PFAM protein family HMMPF00180 InterPro: Isocitrate and isopropylmalate dehydrogenases; High confidence in function and specificity. (383 aa)    
Predicted Functional Partners:
ilvN
Acetolactate synthase, small subunit; Identified by sequence similarity; putative identified by match to TIGR protein family HMMTIGR00119 InterPro: Acetolactate synthase small subunit; High confidence in function and specificity.
  
 0.969
ilvB-1
Acetolactate synthase, large subunit; Identified by sequence similarity; putative InterPro: Acetolactate synthase large subunit biosynthetic type; High confidence in function and specificity.
 0.952
ilvB-2
Acetolactate synthase, large subunit; Identified by sequence similarity; putative InterPro: Thiamine pyrophosphate dependent enzyme; High confidence in function and specificity; Belongs to the TPP enzyme family.
 
 0.943
leuC
3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate.
 
 0.939
leuD
3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily.
  
 0.897
ABO_0509
(aminotransferase, putative) identified by sequence similarity; putative identified by match to PFAM protein family HMMPF00202 InterPro: Aminotransferase class-III pyridoxal-phosphate; Specificity unclear; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
   
 0.725
ABO_0508
(D-isomer specific 2-hydroxyacid dehydrogenase family protein) identified by match to PFAM protein family HMMPF00389; putative InterPro: D-isomer specific 2-hydroxyacid dehydrogenase; Family membership.
 
  
 0.692
leuA-2
2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
 
 
 0.635
gabD
(succinate-semialdehyde dehydrogenase) identified by sequencesimilarity; putative InterPro: Aldehyde dehydrogenase family; High confidence in function and specificity; Belongs to the aldehyde dehydrogenase family.
   
 0.632
ilvC
Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
 
  
 0.618
Your Current Organism:
Alcanivorax borkumensis
NCBI taxonomy Id: 393595
Other names: A. borkumensis SK2, Alcanivorax borkumensis SK2, Alcanivorax borkumensis str. SK2, Alcanivorax borkumensis strain SK2
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