node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABO_0553 | lpxA | ABO_0553 | ABO_1155 | ABC transporter, ATP-binding protein, putative; Identified by match to TIGR protein family HMMTIGR00968 InterPro: AAA ATPase superfamily; Specificity unclear. | acyl-[acyl-carrier-protein]--UDP-N-acetylglucosa mine O-acyl; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | 0.792 |
ABO_0553 | murA | ABO_0553 | ABO_0560 | ABC transporter, ATP-binding protein, putative; Identified by match to TIGR protein family HMMTIGR00968 InterPro: AAA ATPase superfamily; Specificity unclear. | UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. | 0.881 |
galE | glmU | ABO_0909 | ABO_2724 | 4-epimerase; Identified by match to TIGR protein family HMMTIGR01746; putative InterPro: Nucleoside-diphosphate dependent epimerase/dehydratase family; Specificity unclear. | Bifunctional glmU protein; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. In the C-terminal section; belongs to the transferase hexapeptide repeat family. | 0.908 |
galE | lpxA | ABO_0909 | ABO_1155 | 4-epimerase; Identified by match to TIGR protein family HMMTIGR01746; putative InterPro: Nucleoside-diphosphate dependent epimerase/dehydratase family; Specificity unclear. | acyl-[acyl-carrier-protein]--UDP-N-acetylglucosa mine O-acyl; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | 0.824 |
galE | murA | ABO_0909 | ABO_0560 | 4-epimerase; Identified by match to TIGR protein family HMMTIGR01746; putative InterPro: Nucleoside-diphosphate dependent epimerase/dehydratase family; Specificity unclear. | UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. | 0.904 |
galE | wbpO | ABO_0909 | ABO_0908 | 4-epimerase; Identified by match to TIGR protein family HMMTIGR01746; putative InterPro: Nucleoside-diphosphate dependent epimerase/dehydratase family; Specificity unclear. | (capsular polysaccharide biosynthesis protein/UDP-glucose dehydrogenase) identified by match to PFAM protein family HMMPF00984 InterPro: UDP-glucose/GDP-mannose dehydrogenase family The UDP-glucose/GDP-mannose dehydrogenases are a small group of enzymes which possesses the ability to catalyze the NAD-dependent 2-fold oxidation of an alcholol to an acid without the release of an aldehyde intermediate; Family membership. | 0.988 |
glmU | galE | ABO_2724 | ABO_0909 | Bifunctional glmU protein; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. In the C-terminal section; belongs to the transferase hexapeptide repeat family. | 4-epimerase; Identified by match to TIGR protein family HMMTIGR01746; putative InterPro: Nucleoside-diphosphate dependent epimerase/dehydratase family; Specificity unclear. | 0.908 |
glmU | lpxA | ABO_2724 | ABO_1155 | Bifunctional glmU protein; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. In the C-terminal section; belongs to the transferase hexapeptide repeat family. | acyl-[acyl-carrier-protein]--UDP-N-acetylglucosa mine O-acyl; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | 0.847 |
glmU | murA | ABO_2724 | ABO_0560 | Bifunctional glmU protein; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. In the C-terminal section; belongs to the transferase hexapeptide repeat family. | UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. | 0.948 |
glmU | murC | ABO_2724 | ABO_0599 | Bifunctional glmU protein; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. In the C-terminal section; belongs to the transferase hexapeptide repeat family. | UDP-N-acetylmuramate--L-alanine ligase; Cell wall formation; Belongs to the MurCDEF family. | 0.910 |
glmU | murD | ABO_2724 | ABO_0596 | Bifunctional glmU protein; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. In the C-terminal section; belongs to the transferase hexapeptide repeat family. | UDP-N-acetylmuramoylalanine--D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. | 0.480 |
glmU | murE | ABO_2724 | ABO_0593 | Bifunctional glmU protein; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. In the C-terminal section; belongs to the transferase hexapeptide repeat family. | UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily. | 0.912 |
glmU | wbpO | ABO_2724 | ABO_0908 | Bifunctional glmU protein; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. In the C-terminal section; belongs to the transferase hexapeptide repeat family. | (capsular polysaccharide biosynthesis protein/UDP-glucose dehydrogenase) identified by match to PFAM protein family HMMPF00984 InterPro: UDP-glucose/GDP-mannose dehydrogenase family The UDP-glucose/GDP-mannose dehydrogenases are a small group of enzymes which possesses the ability to catalyze the NAD-dependent 2-fold oxidation of an alcholol to an acid without the release of an aldehyde intermediate; Family membership. | 0.921 |
hisG | murA | ABO_0561 | ABO_0560 | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. | 0.862 |
lpxA | ABO_0553 | ABO_1155 | ABO_0553 | acyl-[acyl-carrier-protein]--UDP-N-acetylglucosa mine O-acyl; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | ABC transporter, ATP-binding protein, putative; Identified by match to TIGR protein family HMMTIGR00968 InterPro: AAA ATPase superfamily; Specificity unclear. | 0.792 |
lpxA | galE | ABO_1155 | ABO_0909 | acyl-[acyl-carrier-protein]--UDP-N-acetylglucosa mine O-acyl; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | 4-epimerase; Identified by match to TIGR protein family HMMTIGR01746; putative InterPro: Nucleoside-diphosphate dependent epimerase/dehydratase family; Specificity unclear. | 0.824 |
lpxA | glmU | ABO_1155 | ABO_2724 | acyl-[acyl-carrier-protein]--UDP-N-acetylglucosa mine O-acyl; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | Bifunctional glmU protein; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. In the C-terminal section; belongs to the transferase hexapeptide repeat family. | 0.847 |
lpxA | murA | ABO_1155 | ABO_0560 | acyl-[acyl-carrier-protein]--UDP-N-acetylglucosa mine O-acyl; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. | 0.879 |
lpxA | wbpO | ABO_1155 | ABO_0908 | acyl-[acyl-carrier-protein]--UDP-N-acetylglucosa mine O-acyl; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | (capsular polysaccharide biosynthesis protein/UDP-glucose dehydrogenase) identified by match to PFAM protein family HMMPF00984 InterPro: UDP-glucose/GDP-mannose dehydrogenase family The UDP-glucose/GDP-mannose dehydrogenases are a small group of enzymes which possesses the ability to catalyze the NAD-dependent 2-fold oxidation of an alcholol to an acid without the release of an aldehyde intermediate; Family membership. | 0.815 |
murA | ABO_0553 | ABO_0560 | ABO_0553 | UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. | ABC transporter, ATP-binding protein, putative; Identified by match to TIGR protein family HMMTIGR00968 InterPro: AAA ATPase superfamily; Specificity unclear. | 0.881 |