STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
purBAdenylosuccinate lyase; purB identified by sequencesimilarity; putative InterPro: Adenylosuccinate lyase; High confidence in function and specificity; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (456 aa)    
Predicted Functional Partners:
purL
Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.
 
  
 0.999
purA
Adenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.
 0.997
purC
(phosphoribosylaminoimidazole-succinocarboxamidesyn thase) identified by sequence similarity; putative InterPro: SAICAR synthetase; High confidence in function and specificity.
 
 0.990
purH
(phosphoribosylaminoimidazolecarboxamideformyltrans feras e/IMP cyclohydrolase) identified by sequence similarity; putative; High confidence in function and specificity.
  
 0.987
adk
Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family.
   
 0.948
argH
Argininosuccinate lyase; Identified by sequence similarity; putative identified by match to TIGRFAM protein family HMMTIGR00838 InterPro: Delta crystallin; High confidence in function and specificity.
    
 0.917
ABO_0657
(decarboxylase family protein) identified by sequencesimilarity; putative; Family membership.
  
 
  0.905
trmU
tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
 
  
 0.901
ABO_1622
(MazG nucleotide pyrophosphohydrolase domain family protein) identified by match to TIGR protein family HMMTIGR00444 InterPro: MazG family protein; Function unclear.
    
  0.901
ABO_0278
Identified by match to PFAM protein family HMMPF00702 InterPro: Haloacid dehalogenase/epoxide hydrolase family; Family membership.
    
  0.900
Your Current Organism:
Alcanivorax borkumensis
NCBI taxonomy Id: 393595
Other names: A. borkumensis SK2, Alcanivorax borkumensis SK2, Alcanivorax borkumensis str. SK2, Alcanivorax borkumensis strain SK2
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