Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Co-expression
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[Homology]
Score
icdA(icd) (isocitrate dehydrogenase NADP-dependentprokaryotic-type) identified by match to TIGR protein family HMMTIGR00183 InterPro: Isocitrate dehydrogenase NADP-dependent prok type; High confidence in function and specificity. (420 aa)    
Predicted Functional Partners:
acnA
Aconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate.
 
 0.985
acnB
Aconitate hydratase 2; Identified by sequence similarity; putative InterPro: Aconitate hydratase 2; High confidence in function and specificity; Belongs to the aconitase/IPM isomerase family.
  
 
 0.982
sucA
(kgdA) (2-oxoglutarate dehydrogenase E1 component) identified by sequence similarity; putative InterPro: Dehydrogenase E1 component; High confidence in function and specificity.
   
 0.981
fumA
Fumarate hydratase, putative; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family.
  
  
 0.960
icd
(isocitrate dehydrogenase NADP-dependent, oxalosuccinate decarboxylase) identified by sequence similarity; putative identified by match to PFAM protein family HMMPF00180 and TIGRFAM protein family HMMTIGR00175 InterPro: Isocitrate and isopropylmalate dehydrogenases; High confidence in function and specificity.
 
0.958
icd-2
(isocitrate dehydrogenase NADP-dependent monomeric-type) identified by match to PFAM protein family HMMPF03971 InterPro: Isocitrate dehydrogenase NADP-dependent monomeric type; High confidence in function and specificity; Belongs to the monomeric-type IDH family.
    
 0.957
mdh
Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family.
  
 0.944
gltB
Glutamate synthase, large subunit; Identified by sequencesimilarity; putative identified by match to PFAM protein family HMMPF04897 and HMMPF01645 InterPro: Ferredoxin-dependent glutamate synthase; High confidence in function and specificity.
    
 0.898
sucC
succinyl-CoA synthetase, beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
  
 0.892
gdhA-2
(glutamate dehydrogenase, NAD(P)-specific glutamate dehydrogenase) identified by sequence similarity; putative identified by match to PFAM protein families HMMPF02812 and HMMPF00208 InterPro: Glutamate/leucine/phenylalanine/valine dehydrogenase; High confidence in function and specificity; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
   
 0.879
Your Current Organism:
Alcanivorax borkumensis
NCBI taxonomy Id: 393595
Other names: A. borkumensis SK2, Alcanivorax borkumensis SK2, Alcanivorax borkumensis str. SK2, Alcanivorax borkumensis strain SK2
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