node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABO_0252 | cysG | ABO_0252 | ABO_1295 | Conserved hypothetical protein. | uroporphyrin-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | 0.997 |
ABO_0252 | cysH | ABO_0252 | ABO_1686 | Conserved hypothetical protein. | Phosphoadenosine phosphosulfate reductase; Reduction of activated sulfate into sulfite. | 0.429 |
cysC; | cysG | ABO_0930 | ABO_1295 | Adenylylsulfate kinase; Catalyzes the synthesis of activated sulfate. | uroporphyrin-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | 0.968 |
cysC; | cysH | ABO_0930 | ABO_1686 | Adenylylsulfate kinase; Catalyzes the synthesis of activated sulfate. | Phosphoadenosine phosphosulfate reductase; Reduction of activated sulfate into sulfite. | 0.998 |
cysC; | cysI | ABO_0930 | ABO_1188 | Adenylylsulfate kinase; Catalyzes the synthesis of activated sulfate. | Sulfite reductase (NADPH); (sulphite reductase hemoprotein beta subunit) identified by sequence similarity;putative InterPro: Nitrite and sulfite reductase; High confidence in function and specificity. | 0.711 |
cysC; | sopT | ABO_0930 | ABO_0730 | Adenylylsulfate kinase; Catalyzes the synthesis of activated sulfate. | (sopT; SAT) (Sulfate adenylatetransferase) (ATP-sulfurylase). identified by Glimmer2; InterPro: ATP-sulfurylase Pfam: ATP-sulfurylase; High confidence in function and specificity; Belongs to the sulfate adenylyltransferase family. | 0.998 |
cysG | ABO_0252 | ABO_1295 | ABO_0252 | uroporphyrin-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | Conserved hypothetical protein. | 0.997 |
cysG | cysC; | ABO_1295 | ABO_0930 | uroporphyrin-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | Adenylylsulfate kinase; Catalyzes the synthesis of activated sulfate. | 0.968 |
cysG | cysH | ABO_1295 | ABO_1686 | uroporphyrin-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | Phosphoadenosine phosphosulfate reductase; Reduction of activated sulfate into sulfite. | 0.989 |
cysG | cysI | ABO_1295 | ABO_1188 | uroporphyrin-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | Sulfite reductase (NADPH); (sulphite reductase hemoprotein beta subunit) identified by sequence similarity;putative InterPro: Nitrite and sulfite reductase; High confidence in function and specificity. | 0.930 |
cysG | hemB | ABO_1295 | ABO_2459 | uroporphyrin-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | Porphobilinogen synthase identified by sequence similarity; putative InterPro: Delta-aminolevulinic acid dehydratase; High confidence in function and specificity; Belongs to the ALAD family. | 0.917 |
cysG | hemC | ABO_1295 | ABO_2322 | uroporphyrin-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.995 |
cysG | hemD | ABO_1295 | ABO_2321 | uroporphyrin-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.972 |
cysG | hemE | ABO_1295 | ABO_2227 | uroporphyrin-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.950 |
cysG | hemX | ABO_1295 | ABO_2320 | uroporphyrin-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | uroporphyrin-III C-methyltransferase, putative; Identified by sequence similarity; putative; Hypothetical protein. | 0.911 |
cysG | sopT | ABO_1295 | ABO_0730 | uroporphyrin-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | (sopT; SAT) (Sulfate adenylatetransferase) (ATP-sulfurylase). identified by Glimmer2; InterPro: ATP-sulfurylase Pfam: ATP-sulfurylase; High confidence in function and specificity; Belongs to the sulfate adenylyltransferase family. | 0.954 |
cysH | ABO_0252 | ABO_1686 | ABO_0252 | Phosphoadenosine phosphosulfate reductase; Reduction of activated sulfate into sulfite. | Conserved hypothetical protein. | 0.429 |
cysH | cysC; | ABO_1686 | ABO_0930 | Phosphoadenosine phosphosulfate reductase; Reduction of activated sulfate into sulfite. | Adenylylsulfate kinase; Catalyzes the synthesis of activated sulfate. | 0.998 |
cysH | cysG | ABO_1686 | ABO_1295 | Phosphoadenosine phosphosulfate reductase; Reduction of activated sulfate into sulfite. | uroporphyrin-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | 0.989 |
cysH | cysI | ABO_1686 | ABO_1188 | Phosphoadenosine phosphosulfate reductase; Reduction of activated sulfate into sulfite. | Sulfite reductase (NADPH); (sulphite reductase hemoprotein beta subunit) identified by sequence similarity;putative InterPro: Nitrite and sulfite reductase; High confidence in function and specificity. | 0.986 |