STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
cysGuroporphyrin-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. (461 aa)    
Predicted Functional Partners:
ABO_0252
Conserved hypothetical protein.
  
 
 0.997
hemC
Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.
  
 0.995
cysH
Phosphoadenosine phosphosulfate reductase; Reduction of activated sulfate into sulfite.
 
  
 0.978
hemD
uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.
 
 
 0.972
hemE
Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
    
 0.962
cysC;
Adenylylsulfate kinase; Catalyzes the synthesis of activated sulfate.
  
  
 0.957
cysI
Sulfite reductase (NADPH); (sulphite reductase hemoprotein beta subunit) identified by sequence similarity;putative InterPro: Nitrite and sulfite reductase; High confidence in function and specificity.
 
  
 0.932
sopT
(sopT; SAT) (Sulfate adenylatetransferase) (ATP-sulfurylase). identified by Glimmer2; InterPro: ATP-sulfurylase Pfam: ATP-sulfurylase; High confidence in function and specificity; Belongs to the sulfate adenylyltransferase family.
 
  
 0.924
hemB
Porphobilinogen synthase identified by sequence similarity; putative InterPro: Delta-aminolevulinic acid dehydratase; High confidence in function and specificity; Belongs to the ALAD family.
 
  
 0.921
hemX
uroporphyrin-III C-methyltransferase, putative; Identified by sequence similarity; putative; Hypothetical protein.
     
 0.908
Your Current Organism:
Alcanivorax borkumensis
NCBI taxonomy Id: 393595
Other names: A. borkumensis SK2, Alcanivorax borkumensis SK2, Alcanivorax borkumensis str. SK2, Alcanivorax borkumensis strain SK2
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