Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
czcC1Cobalt/zinc/cadmium efflux RND transporter outermembrane protein (CzcC family) identified by sequencesimilarity; putative InterPro: Outer membrane efflux protein; Family membership. (436 aa)    
Predicted Functional Partners:
czcB1
Heavy metal RND efflux membrane fusion protein (CzcB family) identified by sequence similarity; putative; Family membership.
 
 
 0.959
czcA1
(CzcA) cobalt/zinc/cadmium efflux RND transporterpermease protein (CzcA family) identified by match to PFAM protein family HMMPF04295 InterPro: Heavy metal efflux pump CzcA; Family membership; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
 
  
 0.948
czcB3
(heavy metal RND efflux membrane fusion protein,CzcB family) identified by sequence similarity; putative; Family membership.
 
 
 0.856
czcA3
(cobalt/zinc/cadmium efflux RND transporterpermease protein CzcA family) identified by match to PFAM protein family HMMPF04295 InterPro: Heavy metal efflux pump CzcA; Family membership; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
 
  
 0.811
czcB2
Heavy metal RND efflux membrane fusion protein CzcB family identified by sequence similarity; putative; Family membership; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
 
 
 0.663
macB
ABC transporter, ATP-binding protein/permease, putative; Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides.
  
 
 0.596
ABO_1376
Conserved hypothetical protein.
 
     0.565
czcA
Cation efflux system protein; Identified by match to PFAM protein family HMMPF04295 InterPro: Heavy metal efflux pump CzcA; Family membership; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
 
  
 0.561
ABO_0267
Multidrug resistance protein; Putative secreted protein; Function unclear.
  
 
 0.560
ABO_0854
Conserved hypothetical protein.
  
   
 0.527
Your Current Organism:
Alcanivorax borkumensis
NCBI taxonomy Id: 393595
Other names: A. borkumensis SK2, Alcanivorax borkumensis SK2, Alcanivorax borkumensis str. SK2, Alcanivorax borkumensis strain SK2
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