Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
metZO-succinylhomoserine sulfhydrylase; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide. (404 aa)    
Predicted Functional Partners:
ABO_1324
5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
  
 
 0.979
metX
Homoserine O-acetyltransferase; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine.
  
 0.977
cysK
(cysteine synthase A, O-acetylserine sulfhydrylase A, O- acetylserine (thiol)-lyase A, sulfate starvation-induced protein 5) identified by sequencesimilarity; putative InterPro: Pyridoxal-5-phosphate-dependent enzymes beta family; High confidence in function and specificity; Belongs to the cysteine synthase/cystathionine beta- synthase family.
 
 0.976
metE
5-methyltetrahydropteroyltriglutamate-homocystei ne methyltra; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family.
  
 
 0.962
metY
(O-acetylhomoserine sulfhydrylase, O-acetylhomoserine (thiol)-lyase, oah sulfhydrylase, homocysteine synthase) identified by sequence similarity; identified by match to PFAM protein family HMMPF01053; putative InterPro: Cys/Met metabolism pyridoxal-phosphate-dependent enzymes; High confidence in function and specificity.
 
 
0.931
ahcy
Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.
  
 0.925
cysI
Sulfite reductase (NADPH); (sulphite reductase hemoprotein beta subunit) identified by sequence similarity;putative InterPro: Nitrite and sulfite reductase; High confidence in function and specificity.
  
 
 0.922
cysI-1
Sulfite reductase (NADPH); Identified by similarity to Pfam protein families PF01077 and PF03460 InterPro: Nitrite and sulfite reductase; High confidence in function and specificity.
  
 
 0.922
cysJ
NADPH-sulfite reductase; Identified by sequence similarity. InterPro: FAD-binding domain; High confidence in function and specificity.
  
 
 0.917
ABO_1942
Conserved hypothetical protein; Identified by sequencesimilarity; putative.
  
 
 0.913
Your Current Organism:
Alcanivorax borkumensis
NCBI taxonomy Id: 393595
Other names: A. borkumensis SK2, Alcanivorax borkumensis SK2, Alcanivorax borkumensis str. SK2, Alcanivorax borkumensis strain SK2
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