node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ilvC | ilvN | ABO_0485 | ABO_0482 | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | Acetolactate synthase, small subunit; Identified by sequence similarity; putative identified by match to TIGR protein family HMMTIGR00119 InterPro: Acetolactate synthase small subunit; High confidence in function and specificity. | 0.995 |
ilvC | leuA | ABO_0485 | ABO_0638 | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.765 |
ilvC | leuA-2 | ABO_0485 | ABO_2437 | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. | 0.758 |
ilvC | leuB | ABO_0485 | ABO_1467 | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.759 |
ilvC | leuC | ABO_0485 | ABO_1470 | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.959 |
ilvC | leuD | ABO_0485 | ABO_1469 | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.866 |
ilvC | tdh | ABO_0485 | ABO_0510 | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | Tartrate dehydrogenase; Identified by sequence similarity; putative identified by match to PFAM protein family HMMPF00180 InterPro: Isocitrate and isopropylmalate dehydrogenases; High confidence in function and specificity. | 0.741 |
ilvC | thrC | ABO_0485 | ABO_0807 | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. | 0.726 |
ilvN | ilvC | ABO_0482 | ABO_0485 | Acetolactate synthase, small subunit; Identified by sequence similarity; putative identified by match to TIGR protein family HMMTIGR00119 InterPro: Acetolactate synthase small subunit; High confidence in function and specificity. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.995 |
ilvN | leuA | ABO_0482 | ABO_0638 | Acetolactate synthase, small subunit; Identified by sequence similarity; putative identified by match to TIGR protein family HMMTIGR00119 InterPro: Acetolactate synthase small subunit; High confidence in function and specificity. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.928 |
ilvN | leuA-2 | ABO_0482 | ABO_2437 | Acetolactate synthase, small subunit; Identified by sequence similarity; putative identified by match to TIGR protein family HMMTIGR00119 InterPro: Acetolactate synthase small subunit; High confidence in function and specificity. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. | 0.921 |
ilvN | leuB | ABO_0482 | ABO_1467 | Acetolactate synthase, small subunit; Identified by sequence similarity; putative identified by match to TIGR protein family HMMTIGR00119 InterPro: Acetolactate synthase small subunit; High confidence in function and specificity. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.970 |
ilvN | leuC | ABO_0482 | ABO_1470 | Acetolactate synthase, small subunit; Identified by sequence similarity; putative identified by match to TIGR protein family HMMTIGR00119 InterPro: Acetolactate synthase small subunit; High confidence in function and specificity. | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.830 |
ilvN | leuD | ABO_0482 | ABO_1469 | Acetolactate synthase, small subunit; Identified by sequence similarity; putative identified by match to TIGR protein family HMMTIGR00119 InterPro: Acetolactate synthase small subunit; High confidence in function and specificity. | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.826 |
ilvN | maeB | ABO_0482 | ABO_2239 | Acetolactate synthase, small subunit; Identified by sequence similarity; putative identified by match to TIGR protein family HMMTIGR00119 InterPro: Acetolactate synthase small subunit; High confidence in function and specificity. | Malic enzyme; Identified by match to PFAM protein family HMMPF00390 InterPro: Malic enzymes; High confidence in function and specificity. | 0.827 |
ilvN | oadA | ABO_0482 | ABO_0844 | Acetolactate synthase, small subunit; Identified by sequence similarity; putative identified by match to TIGR protein family HMMTIGR00119 InterPro: Acetolactate synthase small subunit; High confidence in function and specificity. | Oxaloacetate decarboxylase, alpha subunit; Identified by match to PFAM protein family HMMPF03721 InterPro: HMG-CoA Lyase-like family; High confidence in function and specificity. | 0.801 |
ilvN | tdh | ABO_0482 | ABO_0510 | Acetolactate synthase, small subunit; Identified by sequence similarity; putative identified by match to TIGR protein family HMMTIGR00119 InterPro: Acetolactate synthase small subunit; High confidence in function and specificity. | Tartrate dehydrogenase; Identified by sequence similarity; putative identified by match to PFAM protein family HMMPF00180 InterPro: Isocitrate and isopropylmalate dehydrogenases; High confidence in function and specificity. | 0.965 |
ilvN | thrC | ABO_0482 | ABO_0807 | Acetolactate synthase, small subunit; Identified by sequence similarity; putative identified by match to TIGR protein family HMMTIGR00119 InterPro: Acetolactate synthase small subunit; High confidence in function and specificity. | Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. | 0.554 |
leuA | ilvC | ABO_0638 | ABO_0485 | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.765 |
leuA | ilvN | ABO_0638 | ABO_0482 | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | Acetolactate synthase, small subunit; Identified by sequence similarity; putative identified by match to TIGR protein family HMMTIGR00119 InterPro: Acetolactate synthase small subunit; High confidence in function and specificity. | 0.928 |