STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
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[Homology]
Score
sdhA(succinate dehydrogenase flavoprotein subunit) identified by sequence similarity; putative InterPro: Fumarate reductase/succinate dehydrogenase flavoprotein N-terminal part of an enzyme complex containing four subunits: a flavoprotein, an iron-sulfur, cytochrome b-556, and an hydrophobic anchor protein catalytic activity: succinate + acceptor = fumarate + reduced acceptor; High confidence in function and specificity; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. (572 aa)    
Predicted Functional Partners:
sdhB
(succinate dehydrogenase iron-sulfur protein) identified by match to TIGR protein family HMMTIGR00384 InterPro: Succinate dehydrogenase/fumarate reductase iron-sulfur protein catalytic activity: succinate + ubiquinone = fumarate + ubiquinol; High confidence in function and specificity.
 0.999
sdhD
Succinate dehydrogenase, hydrophobic membrane anchor protein; Membrane-anchoring subunit of succinate dehydrogenase (SDH).
 
 0.999
sdhC
Succinate dehydrogenase, cytochrome b556 subunit; Identified by sequence similarity; putative part of an enzyme complex containing four subunits: a flavoprotein, an iron-sulfur, cytochrome b-556, and an hydrophobic anchor protein; High confidence in function and specificity.
 
 0.999
fumC
Fumarate hydratase, class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
 0.997
sucD
succinyl-CoA synthetase, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
 0.994
sucC
succinyl-CoA synthetase, beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
 0.994
fumA
Fumarate hydratase, putative; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family.
  
 
 0.994
sucA
(kgdA) (2-oxoglutarate dehydrogenase E1 component) identified by sequence similarity; putative InterPro: Dehydrogenase E1 component; High confidence in function and specificity.
 
 
 0.939
ABO_1643
Conserved hypothetical protein; Identified by match to PFAM protein family HMMPF03937.
  
 0.939
gabD
(succinate-semialdehyde dehydrogenase) identified by sequencesimilarity; putative InterPro: Aldehyde dehydrogenase family; High confidence in function and specificity; Belongs to the aldehyde dehydrogenase family.
   
 0.915
Your Current Organism:
Alcanivorax borkumensis
NCBI taxonomy Id: 393595
Other names: A. borkumensis SK2, Alcanivorax borkumensis SK2, Alcanivorax borkumensis str. SK2, Alcanivorax borkumensis strain SK2
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.