Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
algWAlginate biosynthesis negative regulator serine protease AlgW, identified by sequence similarity; putative InterPro: Serine proteases trypsin family; High confidence in function and specificity; Belongs to the peptidase S1C family. (483 aa)    
Predicted Functional Partners:
algS
Sigma factor algU negative regulatory protein AlgS; Identified by match to PFAM protein family HMMPF03872 RseA_N; High confidence in function and specificity.
  
 
 0.939
algM
AlgM protein; Identified by sequence similarity; putative; High confidence in function and specificity.
  
  
 0.761
algN
Negative regulator for alginate biosynthesis; (sigma factor algU regulatory protein AlgN) identified by match to PFAM protein family HMMPF03888; High confidence in function and specificity.
  
  
 0.758
algU
DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog; (RNA polymerase sigma-H factor AlgT) identified by sequence similarity; putative InterPro: Sigma factor ECF subfamily; High confidence in function and specificity; Belongs to the sigma-70 factor family. ECF subfamily.
     
 0.688
lepA
GTP-binding protein LepA, putative; Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner.
 
  
 0.597
ABO_1307
Sensor histidine kinase/respose regulator, contains HisKA, HATPase_c and two Response_reg receiver domains; identified by sequencesimilarity; putative InterPro: Histidine kinase C-terminal; Family membership.
  
  
 0.573
glpK
Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate; Belongs to the FGGY kinase family.
   
 0.566
lepB
(signal peptidase I) identified by sequence similarity; InterPro: Signal peptidase; High confidence in function and specificity; Belongs to the peptidase S26 family.
 
   
 0.537
ABO_0637
Putative membrane protein; Hypothetical protein, TMHMM: reporting 6 transmembrane helices.
   
 0.457
rsfS
Conserved hypothetical protein; Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.
 
   0.457
Your Current Organism:
Alcanivorax borkumensis
NCBI taxonomy Id: 393595
Other names: A. borkumensis SK2, Alcanivorax borkumensis SK2, Alcanivorax borkumensis str. SK2, Alcanivorax borkumensis strain SK2
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