STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
ntrCTwo-component response regulator NtrC; Member of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. Phosphorylated NtrC binds directly to DNA and stimulates the formation of open promoter-sigma54-RNA polymerase complexes. (477 aa)    
Predicted Functional Partners:
ntrB
Sensory box histidine kinase NtrB; Identified by match to PFAM protein family HMMPF02518 InterPro: Histidine kinase C-terminal; High confidence in function and specificity.
 0.998
rpoN
RNA polymerase sigma-54 factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.
 
   
 0.799
ABO_2433
Conserved hypothetical protein, signal transduction protein containing a membrane domain, an EAL and a GGDEF domain and PAS/PAC domain.
  
 
 0.630
ABO_1307
Sensor histidine kinase/respose regulator, contains HisKA, HATPase_c and two Response_reg receiver domains; identified by sequencesimilarity; putative InterPro: Histidine kinase C-terminal; Family membership.
  
 
 0.572
gacS
Sensor/response regulator hybrid; (sensor histidine kinase/response regulator GacS) identified by sequence similarity; putative InterPro: Histidine kinase C-terminal; Family membership.
  
 
 0.532
chpA
ChpA two-component hybrid sensor and regulator, putative identified by match to TIGR protein family HMMTIGR01387 InterPro: Histidine kinase C-terminal still frameshift probable component of chemotactic signal transduction system; Specificity unclear.
  
 
 0.505
ABO_2520
Sensor histidin kinase, contains PAS-fold, HisKA and HATPase_c domains; conserved hypothetical protein.
 
 
 
 0.501
gltB
Glutamate synthase, large subunit; Identified by sequencesimilarity; putative identified by match to PFAM protein family HMMPF04897 and HMMPF01645 InterPro: Ferredoxin-dependent glutamate synthase; High confidence in function and specificity.
      
 0.484
ABO_2155
(two-component protein: Na-solute symporter/sensory box histidinekinase/response regulator putative) identified by match to PFAM protein family HMMPF02518 and HMMPF00072; putative InterPro: Sodium:solute symporter family TMHMM: reportin 12 transmembrane helices; Family membership.
  
 
 0.475
ABO_2443
Conserved hypothetical protein; Identified by sequencesimilarity.
  
 
 0.423
Your Current Organism:
Alcanivorax borkumensis
NCBI taxonomy Id: 393595
Other names: A. borkumensis SK2, Alcanivorax borkumensis SK2, Alcanivorax borkumensis str. SK2, Alcanivorax borkumensis strain SK2
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