Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Co-occurrence
Co-expression
Experiments
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[Homology]
Score
ntrBSensory box histidine kinase NtrB; Identified by match to PFAM protein family HMMPF02518 InterPro: Histidine kinase C-terminal; High confidence in function and specificity. (367 aa)    
Predicted Functional Partners:
ntrC
Two-component response regulator NtrC; Member of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. Phosphorylated NtrC binds directly to DNA and stimulates the formation of open promoter-sigma54-RNA polymerase complexes.
 0.998
glnK-1
Nitrogen regulatory protein P-II; Identified by sequence similarity; putative identified by match to PFAM protein family HMMPF00543 InterPro: Nitrogen regulatory protein P-II; High confidence in function and specificity; Belongs to the P(II) protein family.
  
 
 0.822
glnK-2
Nitrogen regulatory protein P-II; Identified by sequence similarity; putative identified by match to PFAM protein family HMMPF00543 InterPro: Nitrogen regulatory protein P-II; High confidence in function and specificity; Belongs to the P(II) protein family.
  
 
 0.822
glnA
(glutamine synthetase type I, glutamate-ammonia ligase) identified by sequence similarity; putative identified by match to TIGRFAM protein family HMMTIGR00653; High confidence in function and specificity.
  
  
 0.768
hydG
Nitrogen regulation protein NR(I; ) identified by match to PFAM protein family HMMPF00072 InterPro: Sigma-54 factor interaction domain; High confidence in function and specificity.
 
 0.760
ABO_0471
Sigma-54 dependent DNA-binding response regulator.
 
 0.720
ABO_1307
Sensor histidine kinase/respose regulator, contains HisKA, HATPase_c and two Response_reg receiver domains; identified by sequencesimilarity; putative InterPro: Histidine kinase C-terminal; Family membership.
   
 
 0.656
ABO_2519
Response regulator; Identified by match to PFAM protein family HMMPF00072 InterPro: Response regulator receiver domain; Family membership.
 
 
 0.642
glnD
protein-pII uridylyltransferase; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen fixation and metabolism.
  
 
 
 0.625
rpoN
RNA polymerase sigma-54 factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.
 
   
 0.580
Your Current Organism:
Alcanivorax borkumensis
NCBI taxonomy Id: 393595
Other names: A. borkumensis SK2, Alcanivorax borkumensis SK2, Alcanivorax borkumensis str. SK2, Alcanivorax borkumensis strain SK2
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