node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
hisA | hisB | ABO_2279 | ABO_2281 | Phosphoribosylformimino-5-aminoimidazolecarboxam ide ribotide; (1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)met hylideneamino] imidazole-4-carboxamide isomerase, phosphoribosylformimino-5-aminoimidazolecarboxamide ribotide isomerase) identified by sequence similarity; putative identified by match to TIGRFAM protein family HMMTIGR00007 InterPro: Histidine biosynthesis protein; High confidence in function and specificity. | Imidazoleglycerol-phosphate dehydratase; Identified by sequence similarity; putative identified by match to PFAM protein family HMMPF00475 InterPro: Imidazoleglycerol-phosphate dehydratase; High confidence in function and specificity. | 0.992 |
hisA | hisC-1 | ABO_2279 | ABO_0563 | Phosphoribosylformimino-5-aminoimidazolecarboxam ide ribotide; (1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)met hylideneamino] imidazole-4-carboxamide isomerase, phosphoribosylformimino-5-aminoimidazolecarboxamide ribotide isomerase) identified by sequence similarity; putative identified by match to TIGRFAM protein family HMMTIGR00007 InterPro: Histidine biosynthesis protein; High confidence in function and specificity. | (histidinol-phosphate aminotransferase, imidazole acetol-phosphate transaminase) identified by sequence similarity; putative identified by match to PFAM protein family HMMPF00155 InterPro: Aminotransferases class-I; High confidence in function and specificity; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.788 |
hisA | hisD | ABO_2279 | ABO_0562 | Phosphoribosylformimino-5-aminoimidazolecarboxam ide ribotide; (1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)met hylideneamino] imidazole-4-carboxamide isomerase, phosphoribosylformimino-5-aminoimidazolecarboxamide ribotide isomerase) identified by sequence similarity; putative identified by match to TIGRFAM protein family HMMTIGR00007 InterPro: Histidine biosynthesis protein; High confidence in function and specificity. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.968 |
hisA | hisE | ABO_2279 | ABO_2249 | Phosphoribosylformimino-5-aminoimidazolecarboxam ide ribotide; (1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)met hylideneamino] imidazole-4-carboxamide isomerase, phosphoribosylformimino-5-aminoimidazolecarboxamide ribotide isomerase) identified by sequence similarity; putative identified by match to TIGRFAM protein family HMMTIGR00007 InterPro: Histidine biosynthesis protein; High confidence in function and specificity. | phosphoribosyl-ATP pyrophosphatase; Identified by sequence similarity; putative identified by match to PFAM protein family HMMPF01503 InterPro: Phosphoribosyl-ATP pyrophosphohydrolase; High confidence in function and specificity. | 0.959 |
hisA | hisF | ABO_2279 | ABO_2278 | Phosphoribosylformimino-5-aminoimidazolecarboxam ide ribotide; (1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)met hylideneamino] imidazole-4-carboxamide isomerase, phosphoribosylformimino-5-aminoimidazolecarboxamide ribotide isomerase) identified by sequence similarity; putative identified by match to TIGRFAM protein family HMMTIGR00007 InterPro: Histidine biosynthesis protein; High confidence in function and specificity. | Imidazoleglycerol phosphate synthase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.997 |
hisA | hisG | ABO_2279 | ABO_0561 | Phosphoribosylformimino-5-aminoimidazolecarboxam ide ribotide; (1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)met hylideneamino] imidazole-4-carboxamide isomerase, phosphoribosylformimino-5-aminoimidazolecarboxamide ribotide isomerase) identified by sequence similarity; putative identified by match to TIGRFAM protein family HMMTIGR00007 InterPro: Histidine biosynthesis protein; High confidence in function and specificity. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.962 |
hisA | hisH | ABO_2279 | ABO_2280 | Phosphoribosylformimino-5-aminoimidazolecarboxam ide ribotide; (1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)met hylideneamino] imidazole-4-carboxamide isomerase, phosphoribosylformimino-5-aminoimidazolecarboxamide ribotide isomerase) identified by sequence similarity; putative identified by match to TIGRFAM protein family HMMTIGR00007 InterPro: Histidine biosynthesis protein; High confidence in function and specificity. | Glutamine amidotransferase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.999 |
hisA | hisI | ABO_2279 | ABO_2134 | Phosphoribosylformimino-5-aminoimidazolecarboxam ide ribotide; (1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)met hylideneamino] imidazole-4-carboxamide isomerase, phosphoribosylformimino-5-aminoimidazolecarboxamide ribotide isomerase) identified by sequence similarity; putative identified by match to TIGRFAM protein family HMMTIGR00007 InterPro: Histidine biosynthesis protein; High confidence in function and specificity. | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.999 |
hisA | hisZ | ABO_2279 | ABO_2198 | Phosphoribosylformimino-5-aminoimidazolecarboxam ide ribotide; (1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)met hylideneamino] imidazole-4-carboxamide isomerase, phosphoribosylformimino-5-aminoimidazolecarboxamide ribotide isomerase) identified by sequence similarity; putative identified by match to TIGRFAM protein family HMMTIGR00007 InterPro: Histidine biosynthesis protein; High confidence in function and specificity. | ATP phosphoribosyl transferase regulatory subunit, putative; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. | 0.867 |
hisA | purH | ABO_2279 | ABO_2015 | Phosphoribosylformimino-5-aminoimidazolecarboxam ide ribotide; (1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)met hylideneamino] imidazole-4-carboxamide isomerase, phosphoribosylformimino-5-aminoimidazolecarboxamide ribotide isomerase) identified by sequence similarity; putative identified by match to TIGRFAM protein family HMMTIGR00007 InterPro: Histidine biosynthesis protein; High confidence in function and specificity. | (phosphoribosylaminoimidazolecarboxamideformyltrans feras e/IMP cyclohydrolase) identified by sequence similarity; putative; High confidence in function and specificity. | 0.497 |
hisB | hisA | ABO_2281 | ABO_2279 | Imidazoleglycerol-phosphate dehydratase; Identified by sequence similarity; putative identified by match to PFAM protein family HMMPF00475 InterPro: Imidazoleglycerol-phosphate dehydratase; High confidence in function and specificity. | Phosphoribosylformimino-5-aminoimidazolecarboxam ide ribotide; (1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)met hylideneamino] imidazole-4-carboxamide isomerase, phosphoribosylformimino-5-aminoimidazolecarboxamide ribotide isomerase) identified by sequence similarity; putative identified by match to TIGRFAM protein family HMMTIGR00007 InterPro: Histidine biosynthesis protein; High confidence in function and specificity. | 0.992 |
hisB | hisC-1 | ABO_2281 | ABO_0563 | Imidazoleglycerol-phosphate dehydratase; Identified by sequence similarity; putative identified by match to PFAM protein family HMMPF00475 InterPro: Imidazoleglycerol-phosphate dehydratase; High confidence in function and specificity. | (histidinol-phosphate aminotransferase, imidazole acetol-phosphate transaminase) identified by sequence similarity; putative identified by match to PFAM protein family HMMPF00155 InterPro: Aminotransferases class-I; High confidence in function and specificity; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.998 |
hisB | hisD | ABO_2281 | ABO_0562 | Imidazoleglycerol-phosphate dehydratase; Identified by sequence similarity; putative identified by match to PFAM protein family HMMPF00475 InterPro: Imidazoleglycerol-phosphate dehydratase; High confidence in function and specificity. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.996 |
hisB | hisE | ABO_2281 | ABO_2249 | Imidazoleglycerol-phosphate dehydratase; Identified by sequence similarity; putative identified by match to PFAM protein family HMMPF00475 InterPro: Imidazoleglycerol-phosphate dehydratase; High confidence in function and specificity. | phosphoribosyl-ATP pyrophosphatase; Identified by sequence similarity; putative identified by match to PFAM protein family HMMPF01503 InterPro: Phosphoribosyl-ATP pyrophosphohydrolase; High confidence in function and specificity. | 0.947 |
hisB | hisF | ABO_2281 | ABO_2278 | Imidazoleglycerol-phosphate dehydratase; Identified by sequence similarity; putative identified by match to PFAM protein family HMMPF00475 InterPro: Imidazoleglycerol-phosphate dehydratase; High confidence in function and specificity. | Imidazoleglycerol phosphate synthase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.998 |
hisB | hisG | ABO_2281 | ABO_0561 | Imidazoleglycerol-phosphate dehydratase; Identified by sequence similarity; putative identified by match to PFAM protein family HMMPF00475 InterPro: Imidazoleglycerol-phosphate dehydratase; High confidence in function and specificity. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.968 |
hisB | hisH | ABO_2281 | ABO_2280 | Imidazoleglycerol-phosphate dehydratase; Identified by sequence similarity; putative identified by match to PFAM protein family HMMPF00475 InterPro: Imidazoleglycerol-phosphate dehydratase; High confidence in function and specificity. | Glutamine amidotransferase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.999 |
hisB | hisI | ABO_2281 | ABO_2134 | Imidazoleglycerol-phosphate dehydratase; Identified by sequence similarity; putative identified by match to PFAM protein family HMMPF00475 InterPro: Imidazoleglycerol-phosphate dehydratase; High confidence in function and specificity. | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.990 |
hisB | hisZ | ABO_2281 | ABO_2198 | Imidazoleglycerol-phosphate dehydratase; Identified by sequence similarity; putative identified by match to PFAM protein family HMMPF00475 InterPro: Imidazoleglycerol-phosphate dehydratase; High confidence in function and specificity. | ATP phosphoribosyl transferase regulatory subunit, putative; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. | 0.870 |
hisC-1 | hisA | ABO_0563 | ABO_2279 | (histidinol-phosphate aminotransferase, imidazole acetol-phosphate transaminase) identified by sequence similarity; putative identified by match to PFAM protein family HMMPF00155 InterPro: Aminotransferases class-I; High confidence in function and specificity; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | Phosphoribosylformimino-5-aminoimidazolecarboxam ide ribotide; (1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)met hylideneamino] imidazole-4-carboxamide isomerase, phosphoribosylformimino-5-aminoimidazolecarboxamide ribotide isomerase) identified by sequence similarity; putative identified by match to TIGRFAM protein family HMMTIGR00007 InterPro: Histidine biosynthesis protein; High confidence in function and specificity. | 0.788 |