| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ABO_2284 | ABO_2286 | ABO_2284 | ABO_2286 | Conserved hypothetical protein; Identified by Glimmer2; putative. | Conserved hypothetical protein; Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and/or repair of Fe-S clusters in biosynthetic enzymes. | 0.583 |
| ABO_2284 | mutY | ABO_2284 | ABO_2285 | Conserved hypothetical protein; Identified by Glimmer2; putative. | A/G specific adenine glycosylase; Adenine glycosylase active on G-A mispairs. | 0.674 |
| ABO_2286 | ABO_2284 | ABO_2286 | ABO_2284 | Conserved hypothetical protein; Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and/or repair of Fe-S clusters in biosynthetic enzymes. | Conserved hypothetical protein; Identified by Glimmer2; putative. | 0.583 |
| ABO_2286 | mutY | ABO_2286 | ABO_2285 | Conserved hypothetical protein; Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and/or repair of Fe-S clusters in biosynthetic enzymes. | A/G specific adenine glycosylase; Adenine glycosylase active on G-A mispairs. | 0.754 |
| ada | mutM | ABO_1412 | ABO_2583 | methylated-DNA-[protein]-cysteine S-methyltransferase; (adaptive response regulator protein) identified by match to PFAM protein family HMMPF01035 InterPro: Methylated-DNA--protein-cysteine methyltransferase AraC type helix-turn-helix; High confidence in function and specificity. | formamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. | 0.490 |
| ada | mutY | ABO_1412 | ABO_2285 | methylated-DNA-[protein]-cysteine S-methyltransferase; (adaptive response regulator protein) identified by match to PFAM protein family HMMPF01035 InterPro: Methylated-DNA--protein-cysteine methyltransferase AraC type helix-turn-helix; High confidence in function and specificity. | A/G specific adenine glycosylase; Adenine glycosylase active on G-A mispairs. | 0.511 |
| ada | polA | ABO_1412 | ABO_2659 | methylated-DNA-[protein]-cysteine S-methyltransferase; (adaptive response regulator protein) identified by match to PFAM protein family HMMPF01035 InterPro: Methylated-DNA--protein-cysteine methyltransferase AraC type helix-turn-helix; High confidence in function and specificity. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.670 |
| ada | ruvB | ABO_1412 | ABO_0753 | methylated-DNA-[protein]-cysteine S-methyltransferase; (adaptive response regulator protein) identified by match to PFAM protein family HMMPF01035 InterPro: Methylated-DNA--protein-cysteine methyltransferase AraC type helix-turn-helix; High confidence in function and specificity. | Holliday junction DNA helicase RuvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. | 0.511 |
| ada | xthA | ABO_1412 | ABO_1485 | methylated-DNA-[protein]-cysteine S-methyltransferase; (adaptive response regulator protein) identified by match to PFAM protein family HMMPF01035 InterPro: Methylated-DNA--protein-cysteine methyltransferase AraC type helix-turn-helix; High confidence in function and specificity. | (xth), (Exonuclease III),(EXO III),(APendonuclease VI). identified by sequencesimilarity; putative InterPro: AP endonucleases family 1 Exodeoxyribonuclease III xth; High confidence in function and specificity. | 0.528 |
| dnaN | mutL | ABO_0002 | ABO_2205 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | DNA mismatch repair protein MutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. | 0.939 |
| dnaN | mutY | ABO_0002 | ABO_2285 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | A/G specific adenine glycosylase; Adenine glycosylase active on G-A mispairs. | 0.831 |
| dnaN | polA | ABO_0002 | ABO_2659 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.993 |
| dnaN | xthA | ABO_0002 | ABO_1485 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | (xth), (Exonuclease III),(EXO III),(APendonuclease VI). identified by sequencesimilarity; putative InterPro: AP endonucleases family 1 Exodeoxyribonuclease III xth; High confidence in function and specificity. | 0.892 |
| mutL | dnaN | ABO_2205 | ABO_0002 | DNA mismatch repair protein MutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.939 |
| mutL | mutM | ABO_2205 | ABO_2583 | DNA mismatch repair protein MutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. | formamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. | 0.446 |
| mutL | mutY | ABO_2205 | ABO_2285 | DNA mismatch repair protein MutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. | A/G specific adenine glycosylase; Adenine glycosylase active on G-A mispairs. | 0.557 |
| mutL | polA | ABO_2205 | ABO_2659 | DNA mismatch repair protein MutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.951 |
| mutL | ruvB | ABO_2205 | ABO_0753 | DNA mismatch repair protein MutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. | Holliday junction DNA helicase RuvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. | 0.451 |
| mutM | ada | ABO_2583 | ABO_1412 | formamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. | methylated-DNA-[protein]-cysteine S-methyltransferase; (adaptive response regulator protein) identified by match to PFAM protein family HMMPF01035 InterPro: Methylated-DNA--protein-cysteine methyltransferase AraC type helix-turn-helix; High confidence in function and specificity. | 0.490 |
| mutM | mutL | ABO_2583 | ABO_2205 | formamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. | DNA mismatch repair protein MutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. | 0.446 |
