STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
hemDuroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. (243 aa)    
Predicted Functional Partners:
hemC
Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.
 
 0.997
hemX
uroporphyrin-III C-methyltransferase, putative; Identified by sequence similarity; putative; Hypothetical protein.
 
 0.980
cysG
uroporphyrin-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme.
 
 
 0.972
hemE
Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
  
 
 0.936
hemB
Porphobilinogen synthase identified by sequence similarity; putative InterPro: Delta-aminolevulinic acid dehydratase; High confidence in function and specificity; Belongs to the ALAD family.
 
 
 0.853
hemY
hemY protein; Identified by sequence similarity; putative InterPro: TPR repeat; Hypothetical protein.
 
   
 0.688
hemA
glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
 
  
 0.599
hemL
(glutamate-1-semialdehyde-21-aminomutase) identified by sequencesimilarity; putative InterPro: Glutamate-1-semialdehyde-21-aminomutase; High confidence in function and specificity.
 
  
 0.494
algR
(Alginate biosynthesis regulatory protein AlgR) identified by sequence similarity; putative InterPro: Response regulator receiver domain Pfam N-terminus: response_rec, Response regulator receiver domain Pfam C-terminus: LytTr; LytTr DNA-binding domain; High confidence in function and specificity.
     
 0.482
ccmC
Heme exporter protein C; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes; Belongs to the CcmC/CycZ/HelC family.
  
    0.469
Your Current Organism:
Alcanivorax borkumensis
NCBI taxonomy Id: 393595
Other names: A. borkumensis SK2, Alcanivorax borkumensis SK2, Alcanivorax borkumensis str. SK2, Alcanivorax borkumensis strain SK2
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