Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
hprAGlycerate dehydrogenase; Identified by sequencesimilarity; putative; High confidence in function and specificity; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (317 aa)    
Predicted Functional Partners:
glcB
Malate synthase; Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl- CoA) and glyoxylate to form malate and CoA; Belongs to the malate synthase family. GlcB subfamily.
  
 
 0.914
aceA
Isocitrate lyase; Identified by sequence similarity; putative InterPro: Isocitrate lyase first step in glyoxylate bypass, an alternative to the tricarboxylic acid cycle (in bacteria, plants, and fungi), belongs to the isocitrate lyase family; High confidence in function and specificity.
     
 0.909
yhaE
2-hydroxy-3-oxopropionate reductase; Identified by sequence similarity; putative; Family membership.
    
 0.908
hyi
Hydroxypyruvate isomerase; Identified by sequencesimilarity; putative; High confidence in function and specificity; Belongs to the hyi family.
   
 
 0.905
dhlA
Haloacid dehalogenase-like hydrolase, putative; Family membership.
    
  0.901
ABO_1062
(hydrolase haloacid dehalogenase-like family) identified by sequencesimilarity; putative InterPro: Haloacid dehalogenase/epoxide hydrolase family; Family membership.
    
  0.901
ABO_2392
Conserved hypothetical protein; Identified by Glimmer2; Pfam: DUF523, Protein of unknown function (DUF523).
       0.598
ABO_2390
(conserved hypothetical protein, non-secretory) TIGR00149; Pfam: UPF0047 Uncharacterised protein family UPF004.
  
    0.566
nnrD
Conserved hypothetical protein; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair o [...]
  
   0.456
ppc
Phosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.
     
 0.452
Your Current Organism:
Alcanivorax borkumensis
NCBI taxonomy Id: 393595
Other names: A. borkumensis SK2, Alcanivorax borkumensis SK2, Alcanivorax borkumensis str. SK2, Alcanivorax borkumensis strain SK2
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