leuA-2 protein (Alcanivorax borkumensis) - STRING interaction network

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leuA-2

2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (559 aa)

Predicted Functional Partners:

leuC

0.978

leuD

0.970

ilvE

0.968

ilvD2

0.953

ilvD-1

0.946

ilvN

0.921

fadA1

0.914

fadAx

0.914

fadA

0.914

ABO_1712

0.914

Your Current Organism:

Alcanivorax borkumensis

NCBI taxonomy Id: 393595
Other names: A. borkumensis SK2, Alcanivorax borkumensis SK2, Alcanivorax borkumensis str. SK2, Alcanivorax borkumensis strain SK2

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABO_1712	fadA	ABO_1712	ABO_1567	acetyl-CoA C-acyltransferase identified by match to PFAM protein family HMMPF00108 InterPro: Thiolase; Function unclear; Belongs to the thiolase-like superfamily. Thiolase family.	(Acetyl CoA acetyltransferase) identified by sequence similarity; putative InterPro: Thiolase; High confidence in function and specificity; Belongs to the thiolase-like superfamily. Thiolase family.	0.850
ABO_1712	fadA1	ABO_1712	ABO_0253	acetyl-CoA C-acyltransferase identified by match to PFAM protein family HMMPF00108 InterPro: Thiolase; Function unclear; Belongs to the thiolase-like superfamily. Thiolase family.	acetyl-CoA acyltransferase; Identified by sequence similarity; High confidence in function and specificity; Belongs to the thiolase-like superfamily. Thiolase family.	0.833
ABO_1712	fadAx	ABO_1712	ABO_0648	acetyl-CoA C-acyltransferase identified by match to PFAM protein family HMMPF00108 InterPro: Thiolase; Function unclear; Belongs to the thiolase-like superfamily. Thiolase family.	acetyl-CoA C-acetyltransferase; (3-ketoacyl-CoA thiolase) identified by sequencesimilarity; putative InterPro: Thiolase; Specificity unclear; Belongs to the thiolase-like superfamily. Thiolase family.	0.848
ABO_1712	leuA-2	ABO_1712	ABO_2437	acetyl-CoA C-acyltransferase identified by match to PFAM protein family HMMPF00108 InterPro: Thiolase; Function unclear; Belongs to the thiolase-like superfamily. Thiolase family.	2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.	0.914
fadA	ABO_1712	ABO_1567	ABO_1712	(Acetyl CoA acetyltransferase) identified by sequence similarity; putative InterPro: Thiolase; High confidence in function and specificity; Belongs to the thiolase-like superfamily. Thiolase family.	acetyl-CoA C-acyltransferase identified by match to PFAM protein family HMMPF00108 InterPro: Thiolase; Function unclear; Belongs to the thiolase-like superfamily. Thiolase family.	0.850
fadA	fadA1	ABO_1567	ABO_0253	(Acetyl CoA acetyltransferase) identified by sequence similarity; putative InterPro: Thiolase; High confidence in function and specificity; Belongs to the thiolase-like superfamily. Thiolase family.	acetyl-CoA acyltransferase; Identified by sequence similarity; High confidence in function and specificity; Belongs to the thiolase-like superfamily. Thiolase family.	0.827
fadA	fadAx	ABO_1567	ABO_0648	(Acetyl CoA acetyltransferase) identified by sequence similarity; putative InterPro: Thiolase; High confidence in function and specificity; Belongs to the thiolase-like superfamily. Thiolase family.	acetyl-CoA C-acetyltransferase; (3-ketoacyl-CoA thiolase) identified by sequencesimilarity; putative InterPro: Thiolase; Specificity unclear; Belongs to the thiolase-like superfamily. Thiolase family.	0.844
fadA	leuA-2	ABO_1567	ABO_2437	(Acetyl CoA acetyltransferase) identified by sequence similarity; putative InterPro: Thiolase; High confidence in function and specificity; Belongs to the thiolase-like superfamily. Thiolase family.	2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.	0.914
fadA1	ABO_1712	ABO_0253	ABO_1712	acetyl-CoA acyltransferase; Identified by sequence similarity; High confidence in function and specificity; Belongs to the thiolase-like superfamily. Thiolase family.	acetyl-CoA C-acyltransferase identified by match to PFAM protein family HMMPF00108 InterPro: Thiolase; Function unclear; Belongs to the thiolase-like superfamily. Thiolase family.	0.833
fadA1	fadA	ABO_0253	ABO_1567	acetyl-CoA acyltransferase; Identified by sequence similarity; High confidence in function and specificity; Belongs to the thiolase-like superfamily. Thiolase family.	(Acetyl CoA acetyltransferase) identified by sequence similarity; putative InterPro: Thiolase; High confidence in function and specificity; Belongs to the thiolase-like superfamily. Thiolase family.	0.827
fadA1	fadAx	ABO_0253	ABO_0648	acetyl-CoA acyltransferase; Identified by sequence similarity; High confidence in function and specificity; Belongs to the thiolase-like superfamily. Thiolase family.	acetyl-CoA C-acetyltransferase; (3-ketoacyl-CoA thiolase) identified by sequencesimilarity; putative InterPro: Thiolase; Specificity unclear; Belongs to the thiolase-like superfamily. Thiolase family.	0.827
fadA1	leuA-2	ABO_0253	ABO_2437	acetyl-CoA acyltransferase; Identified by sequence similarity; High confidence in function and specificity; Belongs to the thiolase-like superfamily. Thiolase family.	2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.	0.914
fadAx	ABO_1712	ABO_0648	ABO_1712	acetyl-CoA C-acetyltransferase; (3-ketoacyl-CoA thiolase) identified by sequencesimilarity; putative InterPro: Thiolase; Specificity unclear; Belongs to the thiolase-like superfamily. Thiolase family.	acetyl-CoA C-acyltransferase identified by match to PFAM protein family HMMPF00108 InterPro: Thiolase; Function unclear; Belongs to the thiolase-like superfamily. Thiolase family.	0.848
fadAx	fadA	ABO_0648	ABO_1567	acetyl-CoA C-acetyltransferase; (3-ketoacyl-CoA thiolase) identified by sequencesimilarity; putative InterPro: Thiolase; Specificity unclear; Belongs to the thiolase-like superfamily. Thiolase family.	(Acetyl CoA acetyltransferase) identified by sequence similarity; putative InterPro: Thiolase; High confidence in function and specificity; Belongs to the thiolase-like superfamily. Thiolase family.	0.844
fadAx	fadA1	ABO_0648	ABO_0253	acetyl-CoA C-acetyltransferase; (3-ketoacyl-CoA thiolase) identified by sequencesimilarity; putative InterPro: Thiolase; Specificity unclear; Belongs to the thiolase-like superfamily. Thiolase family.	acetyl-CoA acyltransferase; Identified by sequence similarity; High confidence in function and specificity; Belongs to the thiolase-like superfamily. Thiolase family.	0.827
fadAx	leuA-2	ABO_0648	ABO_2437	acetyl-CoA C-acetyltransferase; (3-ketoacyl-CoA thiolase) identified by sequencesimilarity; putative InterPro: Thiolase; Specificity unclear; Belongs to the thiolase-like superfamily. Thiolase family.	2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.	0.914
ilvD-1	ilvD2	ABO_0180	ABO_2312	Dihydroxy-acid dehydratase; Identified by sequence similarity; putative identified by match to PFAM protein family HMMPF00920 InterPro: Dihydroxy-acid dehydratase; High confidence in function and specificity; Belongs to the IlvD/Edd family.	Dihydroxy-acid dehydratase; (ilvD-2) identified by sequence similarity; putative identified by match to PFAM protein family HMMPF00920 InterPro: Dihydroxy-acid dehydratase; High confidence in function and specificity; Belongs to the IlvD/Edd family.	0.905
ilvD-1	ilvE	ABO_0180	ABO_2301	Dihydroxy-acid dehydratase; Identified by sequence similarity; putative identified by match to PFAM protein family HMMPF00920 InterPro: Dihydroxy-acid dehydratase; High confidence in function and specificity; Belongs to the IlvD/Edd family.	Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.	0.968
ilvD-1	ilvN	ABO_0180	ABO_0482	Dihydroxy-acid dehydratase; Identified by sequence similarity; putative identified by match to PFAM protein family HMMPF00920 InterPro: Dihydroxy-acid dehydratase; High confidence in function and specificity; Belongs to the IlvD/Edd family.	Acetolactate synthase, small subunit; Identified by sequence similarity; putative identified by match to TIGR protein family HMMTIGR00119 InterPro: Acetolactate synthase small subunit; High confidence in function and specificity.	0.693
ilvD-1	leuA-2	ABO_0180	ABO_2437	Dihydroxy-acid dehydratase; Identified by sequence similarity; putative identified by match to PFAM protein family HMMPF00920 InterPro: Dihydroxy-acid dehydratase; High confidence in function and specificity; Belongs to the IlvD/Edd family.	2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.	0.946

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