STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
thiCThiamin biosynthesis protein ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. (624 aa)    
Predicted Functional Partners:
thiD
Adenine phosphoribosyltransferase; (phosphomethylpyrimidine kinase) identified by sequencesimilarity; putative; High confidence in function and specificity.
 
 0.996
thiG
thiG protein, putative; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
  
 0.986
thiE
Thiamine-phosphate diphosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family.
  
 0.976
ABO_2571
Thiamine biosynthesis protein ThiS; Region start changed from 2912636 to 2912648 (-12 bases).
  
  
 0.929
moeB
Molybdopterin biosynthesis MoeB proteinputative identified by sequencesimilarity; putative InterPro: UBA/THIF-type NAD/FAD binding fold; Family membership.
 
  
 0.879
adpP
ADPribose pyrophosphatase; (ADP-ribose diphosphatase)(Adenosine diphosphoribose pyrophosphatase) (ADPR-PPase) (ADP-ribosephosphohydrolase) belongs to the nudix hydrolase family, nudf subfamily; Family membership.
     
 0.844
ABO_2497
Conserved hypothetical protein.
       0.826
purM
Identified by sequencesimilarity; putative InterPro: Phosphoribosylformylglycinamidine cyclo-ligase; High confidence in function and specificity.
     
 0.805
purK
Phosphoribosylaminoimidazole carboxylase; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR); Belongs to the PurK/PurT family.
     
  0.800
ABO_0609
MutT/nudix family protein/thiamine-phosphatepyrophosphorylase, putative; Identified by sequencesimilarity; putative InterPro: Mutator MutT involved in the go system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine) from dna and the nucleotide pool. 8-oxo-dgtp is inserted opposite da and dc residues of template dna with almost equal efficiency thus leading to a.t to g.c transversions. mutt specifically degrades 8-oxo-dgtp to the monophosphate belongs to the nudix hydrolase family; High confidence in function and specificity.
  
  
 0.793
Your Current Organism:
Alcanivorax borkumensis
NCBI taxonomy Id: 393595
Other names: A. borkumensis SK2, Alcanivorax borkumensis SK2, Alcanivorax borkumensis str. SK2, Alcanivorax borkumensis strain SK2
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