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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
tolC(outer membrane efflux protein TolC) belongs to the prtf family of secretion proteins. Pfam: Outer membrane efflux protein, OEP; Family membership. (481 aa)    
Predicted Functional Partners:
AcrB
AcrB/AcrD/AcrFa family protein; Identified by sequence similarity; putative InterPro: Hydrophobe/amphiphile efflux-1 HAE1; Family membership.
  
 0.961
ABO_0965
(multidrug/solvent RND membrane fusion protein) identified by sequence similarity; putative InterPro: HlyD family secretion protein; High confidence in function and specificity; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
 
 0.952
ABO_2747
(RND efflux membrane fusion protein, putative); identify by sequence similarity, putative; Family membership; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
 
 0.947
ABO_2746
AcrB/AcrD/AcrF family protein; Identified by sequence similarity; putative InterPro: Acriflavin resistance protein The E.coli acrA and acrB genes encode a multi-drug efflux system that isbelieved to protect the bacterium against hydrophobic inhibitors [MEDLINE:94012493]. Members of this family are integral membrane proteins some of which are involved in drug resistance. Proteins which belong to this family (AcrB/AcrD/AcrF family protein) include the P.aeruginosa multidrug resistance protein mexB, A.eutrophus cation efflux system protein czcA, and various R.meliloti nodulation proteins; [...]
  
 0.931
ABO_0250
Outer membrane protein identified by sequence similarity; putative InterPro: Outer membrane efflux protein; Function unclear.
  
  
 0.921
ABO_0963
InterPro: Outer membrane efflux protein probably a component that vonfers multidrug resistance. could also be implicated in the secretion of the siderophore, pyoverdine. probably involved in the efflux of the siderophore across the outer membrane; Hypothetical protein.
  
  
0.911
macB
ABC transporter, ATP-binding protein/permease, putative; Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides.
  
 
 0.878
adpP
ADPribose pyrophosphatase; (ADP-ribose diphosphatase)(Adenosine diphosphoribose pyrophosphatase) (ADPR-PPase) (ADP-ribosephosphohydrolase) belongs to the nudix hydrolase family, nudf subfamily; Family membership.
 
 
   0.675
algL
Alginate lyase, Poly(beta-D-mannuronate lyase)(Poly(mana) alginate lyase, precursor; Family membership.
  
  
 0.659
lptD
Conserved hypothetical protein; Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane.
  
  
 0.635
Your Current Organism:
Alcanivorax borkumensis
NCBI taxonomy Id: 393595
Other names: A. borkumensis SK2, Alcanivorax borkumensis SK2, Alcanivorax borkumensis str. SK2, Alcanivorax borkumensis strain SK2
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