STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
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Co-occurrence
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[Homology]
Score
thiGthiG protein, putative; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (259 aa)    
Predicted Functional Partners:
ABO_2571
Thiamine biosynthesis protein ThiS; Region start changed from 2912636 to 2912648 (-12 bases).
 
 
 0.996
thiE
Thiamine-phosphate diphosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family.
 
 
 0.995
thiC
Thiamin biosynthesis protein ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
  
 0.986
ABO_0470
Oxidoreductase FAD-binding identified by sequencesimilarity; putative InterPro: D-amino acid oxidase; Function unclear.
 
 0.979
moeB
Molybdopterin biosynthesis MoeB proteinputative identified by sequencesimilarity; putative InterPro: UBA/THIF-type NAD/FAD binding fold; Family membership.
  
 0.968
dxs
Deoxyxylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily.
     
 0.940
thiD
Adenine phosphoribosyltransferase; (phosphomethylpyrimidine kinase) identified by sequencesimilarity; putative; High confidence in function and specificity.
 
  
 0.926
ABO_0609
MutT/nudix family protein/thiamine-phosphatepyrophosphorylase, putative; Identified by sequencesimilarity; putative InterPro: Mutator MutT involved in the go system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine) from dna and the nucleotide pool. 8-oxo-dgtp is inserted opposite da and dc residues of template dna with almost equal efficiency thus leading to a.t to g.c transversions. mutt specifically degrades 8-oxo-dgtp to the monophosphate belongs to the nudix hydrolase family; High confidence in function and specificity.
  
  
 0.804
cmoA
Methyltransferase, putative; Catalyzes the conversion of S-adenosyl-L-methionine (SAM) to carboxy-S-adenosyl-L-methionine (Cx-SAM).
    
 0.712
ABO_2570
Conserved hypothetical protein; Identified by sequencesimilarity; putative.
       0.632
Your Current Organism:
Alcanivorax borkumensis
NCBI taxonomy Id: 393595
Other names: A. borkumensis SK2, Alcanivorax borkumensis SK2, Alcanivorax borkumensis str. SK2, Alcanivorax borkumensis strain SK2
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.