| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| aceA | aceF | ABO_2741 | ABO_0623 | Isocitrate lyase; Identified by sequence similarity; putative InterPro: Isocitrate lyase first step in glyoxylate bypass, an alternative to the tricarboxylic acid cycle (in bacteria, plants, and fungi), belongs to the isocitrate lyase family; High confidence in function and specificity. | Pyruvate dehydrogenase, E2 component; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | 0.819 |
| aceA | acnA | ABO_2741 | ABO_0694 | Isocitrate lyase; Identified by sequence similarity; putative InterPro: Isocitrate lyase first step in glyoxylate bypass, an alternative to the tricarboxylic acid cycle (in bacteria, plants, and fungi), belongs to the isocitrate lyase family; High confidence in function and specificity. | Aconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. | 0.921 |
| aceA | acnB | ABO_2741 | ABO_1201 | Isocitrate lyase; Identified by sequence similarity; putative InterPro: Isocitrate lyase first step in glyoxylate bypass, an alternative to the tricarboxylic acid cycle (in bacteria, plants, and fungi), belongs to the isocitrate lyase family; High confidence in function and specificity. | Aconitate hydratase 2; Identified by sequence similarity; putative InterPro: Aconitate hydratase 2; High confidence in function and specificity; Belongs to the aconitase/IPM isomerase family. | 0.922 |
| aceA | acsA | ABO_2741 | ABO_0334 | Isocitrate lyase; Identified by sequence similarity; putative InterPro: Isocitrate lyase first step in glyoxylate bypass, an alternative to the tricarboxylic acid cycle (in bacteria, plants, and fungi), belongs to the isocitrate lyase family; High confidence in function and specificity. | acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. | 0.828 |
| aceA | fadA1 | ABO_2741 | ABO_0253 | Isocitrate lyase; Identified by sequence similarity; putative InterPro: Isocitrate lyase first step in glyoxylate bypass, an alternative to the tricarboxylic acid cycle (in bacteria, plants, and fungi), belongs to the isocitrate lyase family; High confidence in function and specificity. | acetyl-CoA acyltransferase; Identified by sequence similarity; High confidence in function and specificity; Belongs to the thiolase-like superfamily. Thiolase family. | 0.805 |
| aceA | glcB | ABO_2741 | ABO_1267 | Isocitrate lyase; Identified by sequence similarity; putative InterPro: Isocitrate lyase first step in glyoxylate bypass, an alternative to the tricarboxylic acid cycle (in bacteria, plants, and fungi), belongs to the isocitrate lyase family; High confidence in function and specificity. | Malate synthase; Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl- CoA) and glyoxylate to form malate and CoA; Belongs to the malate synthase family. GlcB subfamily. | 0.997 |
| aceA | hprA | ABO_2741 | ABO_2391 | Isocitrate lyase; Identified by sequence similarity; putative InterPro: Isocitrate lyase first step in glyoxylate bypass, an alternative to the tricarboxylic acid cycle (in bacteria, plants, and fungi), belongs to the isocitrate lyase family; High confidence in function and specificity. | Glycerate dehydrogenase; Identified by sequencesimilarity; putative; High confidence in function and specificity; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | 0.909 |
| aceA | prpB | ABO_2741 | ABO_1433 | Isocitrate lyase; Identified by sequence similarity; putative InterPro: Isocitrate lyase first step in glyoxylate bypass, an alternative to the tricarboxylic acid cycle (in bacteria, plants, and fungi), belongs to the isocitrate lyase family; High confidence in function and specificity. | 2-methylisocitrate lyase; Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate. Belongs to the isocitrate lyase/PEP mutase superfamily. Methylisocitrate lyase family. | 0.918 |
| aceA | sucC | ABO_2741 | ABO_1493 | Isocitrate lyase; Identified by sequence similarity; putative InterPro: Isocitrate lyase first step in glyoxylate bypass, an alternative to the tricarboxylic acid cycle (in bacteria, plants, and fungi), belongs to the isocitrate lyase family; High confidence in function and specificity. | succinyl-CoA synthetase, beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. | 0.924 |
| aceA | sucD | ABO_2741 | ABO_1492 | Isocitrate lyase; Identified by sequence similarity; putative InterPro: Isocitrate lyase first step in glyoxylate bypass, an alternative to the tricarboxylic acid cycle (in bacteria, plants, and fungi), belongs to the isocitrate lyase family; High confidence in function and specificity. | succinyl-CoA synthetase, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. | 0.918 |
| aceF | aceA | ABO_0623 | ABO_2741 | Pyruvate dehydrogenase, E2 component; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | Isocitrate lyase; Identified by sequence similarity; putative InterPro: Isocitrate lyase first step in glyoxylate bypass, an alternative to the tricarboxylic acid cycle (in bacteria, plants, and fungi), belongs to the isocitrate lyase family; High confidence in function and specificity. | 0.819 |
| aceF | acnB | ABO_0623 | ABO_1201 | Pyruvate dehydrogenase, E2 component; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | Aconitate hydratase 2; Identified by sequence similarity; putative InterPro: Aconitate hydratase 2; High confidence in function and specificity; Belongs to the aconitase/IPM isomerase family. | 0.417 |
| aceF | acsA | ABO_0623 | ABO_0334 | Pyruvate dehydrogenase, E2 component; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. | 0.905 |
| aceF | fadA1 | ABO_0623 | ABO_0253 | Pyruvate dehydrogenase, E2 component; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | acetyl-CoA acyltransferase; Identified by sequence similarity; High confidence in function and specificity; Belongs to the thiolase-like superfamily. Thiolase family. | 0.916 |
| aceF | glcB | ABO_0623 | ABO_1267 | Pyruvate dehydrogenase, E2 component; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | Malate synthase; Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl- CoA) and glyoxylate to form malate and CoA; Belongs to the malate synthase family. GlcB subfamily. | 0.909 |
| aceF | prpB | ABO_0623 | ABO_1433 | Pyruvate dehydrogenase, E2 component; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | 2-methylisocitrate lyase; Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate. Belongs to the isocitrate lyase/PEP mutase superfamily. Methylisocitrate lyase family. | 0.808 |
| aceF | sucC | ABO_0623 | ABO_1493 | Pyruvate dehydrogenase, E2 component; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | succinyl-CoA synthetase, beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. | 0.964 |
| aceF | sucD | ABO_0623 | ABO_1492 | Pyruvate dehydrogenase, E2 component; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | succinyl-CoA synthetase, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. | 0.947 |
| acnA | aceA | ABO_0694 | ABO_2741 | Aconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. | Isocitrate lyase; Identified by sequence similarity; putative InterPro: Isocitrate lyase first step in glyoxylate bypass, an alternative to the tricarboxylic acid cycle (in bacteria, plants, and fungi), belongs to the isocitrate lyase family; High confidence in function and specificity. | 0.921 |
| acnA | acnB | ABO_0694 | ABO_1201 | Aconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. | Aconitate hydratase 2; Identified by sequence similarity; putative InterPro: Aconitate hydratase 2; High confidence in function and specificity; Belongs to the aconitase/IPM isomerase family. | 0.923 |
