Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
fumCFumarate hydratase, class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (462 aa)    
Predicted Functional Partners:
sdhA
(succinate dehydrogenase flavoprotein subunit) identified by sequence similarity; putative InterPro: Fumarate reductase/succinate dehydrogenase flavoprotein N-terminal part of an enzyme complex containing four subunits: a flavoprotein, an iron-sulfur, cytochrome b-556, and an hydrophobic anchor protein catalytic activity: succinate + acceptor = fumarate + reduced acceptor; High confidence in function and specificity; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.
 0.997
mdh
Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family.
  
 0.981
fumA
Fumarate hydratase, putative; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family.
  
 
 0.973
maeB
Malic enzyme; Identified by match to PFAM protein family HMMPF00390 InterPro: Malic enzymes; High confidence in function and specificity.
 
 
 0.957
sdhB
(succinate dehydrogenase iron-sulfur protein) identified by match to TIGR protein family HMMTIGR00384 InterPro: Succinate dehydrogenase/fumarate reductase iron-sulfur protein catalytic activity: succinate + ubiquinone = fumarate + ubiquinol; High confidence in function and specificity.
  
 0.955
prpC
Methylcitrate synthase putative identified by sequence similarity; putative InterPro: Citrate synthase; High confidence in function and specificity; Belongs to the citrate synthase family.
   
 0.947
gltA
Citrate synthase; Identified by match to PFAM protein family HMMPF00285 InterPro: Citrate synthase; High confidence in function and specificity.
   
 0.947
sdhC
Succinate dehydrogenase, cytochrome b556 subunit; Identified by sequence similarity; putative part of an enzyme complex containing four subunits: a flavoprotein, an iron-sulfur, cytochrome b-556, and an hydrophobic anchor protein; High confidence in function and specificity.
   
 
 0.944
sdhD
Succinate dehydrogenase, hydrophobic membrane anchor protein; Membrane-anchoring subunit of succinate dehydrogenase (SDH).
   
 
 0.924
glcB
Malate synthase; Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl- CoA) and glyoxylate to form malate and CoA; Belongs to the malate synthase family. GlcB subfamily.
  
 
 0.919
Your Current Organism:
Alcanivorax borkumensis
NCBI taxonomy Id: 393595
Other names: A. borkumensis SK2, Alcanivorax borkumensis SK2, Alcanivorax borkumensis str. SK2, Alcanivorax borkumensis strain SK2
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