node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
apt | guaA | SAMN05660472_01576 | SAMN05660472_00363 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 0.989 |
apt | guaB | SAMN05660472_01576 | SAMN05660472_00362 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.916 |
apt | xpt | SAMN05660472_01576 | SAMN05660472_02339 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. | 0.914 |
argS | guaA | SAMN05660472_02026 | SAMN05660472_00363 | arginyl-tRNA synthetase. | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 0.999 |
argS | guaB | SAMN05660472_02026 | SAMN05660472_00362 | arginyl-tRNA synthetase. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.505 |
argS | lysS | SAMN05660472_02026 | SAMN05660472_02205 | arginyl-tRNA synthetase. | lysyl-tRNA synthetase, class II; Belongs to the class-II aminoacyl-tRNA synthetase family. | 0.926 |
argS | rplA | SAMN05660472_02026 | SAMN05660472_03015 | arginyl-tRNA synthetase. | LSU ribosomal protein L1P; Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release. | 0.606 |
argS | rplJ | SAMN05660472_02026 | SAMN05660472_03013 | arginyl-tRNA synthetase. | LSU ribosomal protein L10P; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the universal ribosomal protein uL10 family. | 0.634 |
argS | rplK | SAMN05660472_02026 | SAMN05660472_03016 | arginyl-tRNA synthetase. | Large subunit ribosomal protein L11; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. | 0.669 |
guaA | apt | SAMN05660472_00363 | SAMN05660472_01576 | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.989 |
guaA | argS | SAMN05660472_00363 | SAMN05660472_02026 | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | arginyl-tRNA synthetase. | 0.999 |
guaA | guaB | SAMN05660472_00363 | SAMN05660472_00362 | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.999 |
guaA | lysS | SAMN05660472_00363 | SAMN05660472_02205 | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | lysyl-tRNA synthetase, class II; Belongs to the class-II aminoacyl-tRNA synthetase family. | 0.995 |
guaA | map | SAMN05660472_00363 | SAMN05660472_02756 | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | Methionine aminopeptidase, type I; Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed; Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily. | 0.999 |
guaA | pfkA | SAMN05660472_00363 | SAMN05660472_02613 | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. | 0.991 |
guaA | rplA | SAMN05660472_00363 | SAMN05660472_03015 | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | LSU ribosomal protein L1P; Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release. | 0.990 |
guaA | rplJ | SAMN05660472_00363 | SAMN05660472_03013 | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | LSU ribosomal protein L10P; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the universal ribosomal protein uL10 family. | 0.993 |
guaA | rplK | SAMN05660472_00363 | SAMN05660472_03016 | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | Large subunit ribosomal protein L11; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. | 0.999 |
guaA | xpt | SAMN05660472_00363 | SAMN05660472_02339 | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. | 0.994 |
guaB | apt | SAMN05660472_00362 | SAMN05660472_01576 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.916 |