STRINGSTRING
nadA protein (Sinorhizobium fredii NGR234) - STRING interaction network
"nadA" - Quinolinate synthase A in Sinorhizobium fredii NGR234
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
nadAQuinolinate synthase A; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (359 aa)    
Predicted Functional Partners:
nadB
L-aspartate oxidase; Catalyzes the oxidation of L-aspartate to iminoaspartate (532 aa)
 
  0.999
nadC
Carboxylating nicotinate-nucleotide pyrophosphorylase; Quinolinate phosphoribosyltransferase[decarboxylating]; QAPRTase; Belongs to the NadC/ModD family (318 aa)
 
 
  0.997
smpB
SsrA-binding protein; Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a ’tag peptide’, a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to [...] (159 aa)
         
  0.747
atpC
ATP synthase epsilon chain; Produces ATP from ADP in the presence of a proton gradient across the membrane (134 aa)
           
  0.728
tatB
Sec-independent protein translocase protein TatB; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (229 aa)
         
  0.718
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5’-3’ exonuclease activity (1040 aa)
         
  0.703
nadE2
Glutamine-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source (560 aa)
         
  0.692
NGR_a03710
Uncharacterized HTH-type transcriptional regulator y4fK; y4fK; NGR234_108 (427 aa)
           
  0.673
NGR_c08530
annotation not available (321 aa)
 
     
  0.656
NGR_c08480
annotation not available (413 aa)
         
  0.605
Your Current Organism:
Sinorhizobium fredii NGR234
NCBI taxonomy Id: 394
Other names: Ensifer fredii NGR234, Plasmid pNGR234a, Rhizobium sp. (strain NGR234), Rhizobium sp. NGR234, S. fredii NGR234, Sinorhizobium fredii NGR234, Sinorhizobium sp. NGR234
Server load: low (10%) [HD]