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glyA protein (Sinorhizobium fredii NGR234) - STRING interaction network
"glyA" - Serine hydroxymethyltransferase in Sinorhizobium fredii NGR234
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second shell of interactors
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (459 aa)    
Predicted Functional Partners:
folD2
Bifunctional protein FolD; Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (299 aa)
 
 
  0.994
purH
annotation not available (536 aa)
   
  0.993
gcvP
Glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family (952 aa)
 
 
  0.991
soxA1
annotation not available (997 aa)
   
  0.983
soxA2
annotation not available (987 aa)
   
  0.983
gcvT
annotation not available (474 aa)
 
  0.983
gcvH
Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (120 aa)
   
 
  0.969
fhs
annotation not available (559 aa)
   
  0.968
lpdA1
annotation not available (468 aa)
 
 
  0.963
NGR_c28700
L-threonine aldolase; Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde (348 aa)
     
  0.961
Your Current Organism:
Sinorhizobium fredii NGR234
NCBI taxonomy Id: 394
Other names: Ensifer fredii NGR234, Plasmid pNGR234a, Rhizobium sp. (strain NGR234), Rhizobium sp. NGR234, S. fredii NGR234, Sinorhizobium fredii NGR234, Sinorhizobium sp. NGR234
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