STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hmgAHomogentisate 1,2-dioxygenase; Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate. (453 aa)    
Predicted Functional Partners:
ACP26744.1
4-hydroxyphenylpyruvate dioxygenase.
 
 0.997
ACP26738.1
Maleylacetoacetate isomerase protein.
 
 
 0.996
ACP26739.1
Probable aromatic amino acid degradation protein, fumarylacetoacetate hydrolase family.
 
  
 0.967
ACP26742.1
Putative transcriptional regulator, MarR family.
 
     0.872
ACP25523.1
Predicted fumarylpyruvate hydrolase protein.
  
  
 0.797
ACP26740.1
Putative hydrolase.
       0.790
PhhB
Predicted pterin-4-alpha carbinolamine dehydratase.
  
  
 0.661
purU3
Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4).
       0.423
paaN
Phenylacetic acid degradation protein PaaN.
   
  
 0.411
ACP26486.1
Putative aminotransferase.
   
  
 0.406
Your Current Organism:
Sinorhizobium fredii NGR234
NCBI taxonomy Id: 394
Other names: Ensifer fredii NGR234, Plasmid pNGR234a, Rhizobium sp. (strain NGR234), Rhizobium sp. NGR234, S. fredii NGR234, Sinorhizobium sp. NGR234
Server load: high (82%) [HD]