STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SEP41496.1Uroporphyrinogen III methyltransferase / synthase. (510 aa)    
Predicted Functional Partners:
hemC
Hydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.
 0.999
SEP41500.1
Porphobilinogen synthase; Belongs to the ALAD family.
 
 0.999
SEO78067.1
uroporphyrin-III C-methyltransferase / precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase.
 
 
0.998
SEP52857.1
Precorrin-2 C20-methyltransferase / precorrin-3B C17-methyltransferase; Belongs to the precorrin methyltransferase family.
 
 
 0.995
hemA
glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
 
  
 0.990
hemE
Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
  
 
 0.962
SEP52587.1
uroporphyrinogen-III synthase.
 
 
 0.955
SEP52583.1
uroporphyrinogen-III synthase.
  
 
 0.949
SEP45648.1
Sirohydrochlorin ferrochelatase.
  
 
 0.944
SEP41509.1
Hypothetical protein.
  
    0.926
Your Current Organism:
Amycolatopsis saalfeldensis
NCBI taxonomy Id: 394193
Other names: A. saalfeldensis, Amycolatopsis saalfeldensis Carlsohn et al. 2007, DSM 44993, HKI 0457, JCM 14909, NRRL B-24474
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