node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABI65329.1 | fhs | Mmar10_1036 | Mmar10_1412 | TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; KEGG: rsp:RSP_2221 adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | PFAM: formate-tetrahydrofolate ligase, FTHFS; KEGG: sme:SMc02728 probable formate--tetrahydrofolate ligase protein; Belongs to the formate--tetrahydrofolate ligase family. | 0.530 |
ABI65329.1 | folD | Mmar10_1036 | Mmar10_0051 | TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; KEGG: rsp:RSP_2221 adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 5,10-methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.811 |
ABI65329.1 | glyA | Mmar10_1036 | Mmar10_1537 | TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; KEGG: rsp:RSP_2221 adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.877 |
ABI65329.1 | guaB | Mmar10_1036 | Mmar10_1175 | TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; KEGG: rsp:RSP_2221 adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.850 |
ABI65329.1 | purD | Mmar10_1036 | Mmar10_0627 | TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; KEGG: rsp:RSP_2221 adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | KEGG: rru:Rru_A0646 phosphoribosylamine--glycine ligase; TIGRFAM: phosphoribosylamine--glycine ligase; PFAM: phosphoribosylglycinamide synthetase; protein of unknown function DUF201; Belongs to the GARS family. | 0.964 |
ABI65329.1 | purE | Mmar10_1036 | Mmar10_2567 | TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; KEGG: rsp:RSP_2221 adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 5-(carboxyamino)imidazole ribonucleotide mutase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). | 0.960 |
ABI65329.1 | purF | Mmar10_1036 | Mmar10_1205 | TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; KEGG: rsp:RSP_2221 adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.973 |
ABI65329.1 | purH | Mmar10_1036 | Mmar10_2928 | TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; KEGG: rsp:RSP_2221 adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | IMP cyclohydrolase; KEGG: sil:SPO3374 bifunctional purine biosynthesis protein PurH; TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: AICARFT/IMPCHase bienzyme; MGS domain protein. | 0.996 |
ABI65329.1 | purM | Mmar10_1036 | Mmar10_1247 | TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; KEGG: rsp:RSP_2221 adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | KEGG: ccr:CC1703 phosphoribosylformylglycinamidine cyclo-ligase; TIGRFAM: phosphoribosylformylglycinamidine cyclo-ligase; PFAM: AIR synthase related protein; AIR synthase related protein domain protein. | 0.922 |
ABI65329.1 | purN | Mmar10_1036 | Mmar10_1246 | TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; KEGG: rsp:RSP_2221 adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.900 |
fhs | ABI65329.1 | Mmar10_1412 | Mmar10_1036 | PFAM: formate-tetrahydrofolate ligase, FTHFS; KEGG: sme:SMc02728 probable formate--tetrahydrofolate ligase protein; Belongs to the formate--tetrahydrofolate ligase family. | TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; KEGG: rsp:RSP_2221 adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.530 |
fhs | folD | Mmar10_1412 | Mmar10_0051 | PFAM: formate-tetrahydrofolate ligase, FTHFS; KEGG: sme:SMc02728 probable formate--tetrahydrofolate ligase protein; Belongs to the formate--tetrahydrofolate ligase family. | 5,10-methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.996 |
fhs | glyA | Mmar10_1412 | Mmar10_1537 | PFAM: formate-tetrahydrofolate ligase, FTHFS; KEGG: sme:SMc02728 probable formate--tetrahydrofolate ligase protein; Belongs to the formate--tetrahydrofolate ligase family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.968 |
fhs | purD | Mmar10_1412 | Mmar10_0627 | PFAM: formate-tetrahydrofolate ligase, FTHFS; KEGG: sme:SMc02728 probable formate--tetrahydrofolate ligase protein; Belongs to the formate--tetrahydrofolate ligase family. | KEGG: rru:Rru_A0646 phosphoribosylamine--glycine ligase; TIGRFAM: phosphoribosylamine--glycine ligase; PFAM: phosphoribosylglycinamide synthetase; protein of unknown function DUF201; Belongs to the GARS family. | 0.665 |
fhs | purE | Mmar10_1412 | Mmar10_2567 | PFAM: formate-tetrahydrofolate ligase, FTHFS; KEGG: sme:SMc02728 probable formate--tetrahydrofolate ligase protein; Belongs to the formate--tetrahydrofolate ligase family. | 5-(carboxyamino)imidazole ribonucleotide mutase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). | 0.637 |
fhs | purF | Mmar10_1412 | Mmar10_1205 | PFAM: formate-tetrahydrofolate ligase, FTHFS; KEGG: sme:SMc02728 probable formate--tetrahydrofolate ligase protein; Belongs to the formate--tetrahydrofolate ligase family. | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.742 |
fhs | purH | Mmar10_1412 | Mmar10_2928 | PFAM: formate-tetrahydrofolate ligase, FTHFS; KEGG: sme:SMc02728 probable formate--tetrahydrofolate ligase protein; Belongs to the formate--tetrahydrofolate ligase family. | IMP cyclohydrolase; KEGG: sil:SPO3374 bifunctional purine biosynthesis protein PurH; TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: AICARFT/IMPCHase bienzyme; MGS domain protein. | 0.985 |
fhs | purM | Mmar10_1412 | Mmar10_1247 | PFAM: formate-tetrahydrofolate ligase, FTHFS; KEGG: sme:SMc02728 probable formate--tetrahydrofolate ligase protein; Belongs to the formate--tetrahydrofolate ligase family. | KEGG: ccr:CC1703 phosphoribosylformylglycinamidine cyclo-ligase; TIGRFAM: phosphoribosylformylglycinamidine cyclo-ligase; PFAM: AIR synthase related protein; AIR synthase related protein domain protein. | 0.411 |
fhs | purN | Mmar10_1412 | Mmar10_1246 | PFAM: formate-tetrahydrofolate ligase, FTHFS; KEGG: sme:SMc02728 probable formate--tetrahydrofolate ligase protein; Belongs to the formate--tetrahydrofolate ligase family. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.971 |
folD | ABI65329.1 | Mmar10_0051 | Mmar10_1036 | 5,10-methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; KEGG: rsp:RSP_2221 adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.811 |