node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SFS57363.1 | SFS67463.1 | SAMN04488040_1057 | SAMN04488040_1440 | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | 0.841 |
SFS57363.1 | SFS84686.1 | SAMN04488040_1057 | SAMN04488040_2081 | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | Branched-chain amino acid aminotransferase. | 0.968 |
SFS57363.1 | SFS95183.1 | SAMN04488040_1057 | SAMN04488040_2428 | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | D-alanine transaminase. | 0.945 |
SFS57363.1 | SFS98403.1 | SAMN04488040_1057 | SAMN04488040_2601 | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | Branched-chain amino acid aminotransferase. | 0.977 |
SFS57363.1 | SFT08154.1 | SAMN04488040_1057 | SAMN04488040_3061 | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | Glutamate synthase (NADPH) large subunit. | 0.515 |
SFS57363.1 | ilvC | SAMN04488040_1057 | SAMN04488040_1689 | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.900 |
SFS57363.1 | ilvE | SAMN04488040_1057 | SAMN04488040_3037 | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | Branched chain amino acid aminotransferase apoenzyme; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. | 0.968 |
SFS57363.1 | leuA | SAMN04488040_1057 | SAMN04488040_2490 | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.890 |
SFS57363.1 | leuB | SAMN04488040_1057 | SAMN04488040_3007 | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.947 |
SFS67463.1 | SFS57363.1 | SAMN04488040_1440 | SAMN04488040_1057 | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 0.841 |
SFS67463.1 | SFS67489.1 | SAMN04488040_1440 | SAMN04488040_1442 | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | Fumarylacetoacetate (FAA) hydrolase family protein. | 0.839 |
SFS67463.1 | SFS84686.1 | SAMN04488040_1440 | SAMN04488040_2081 | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | Branched-chain amino acid aminotransferase. | 0.852 |
SFS67463.1 | SFS95183.1 | SAMN04488040_1440 | SAMN04488040_2428 | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | D-alanine transaminase. | 0.843 |
SFS67463.1 | SFS98403.1 | SAMN04488040_1440 | SAMN04488040_2601 | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | Branched-chain amino acid aminotransferase. | 0.904 |
SFS67463.1 | SFT08154.1 | SAMN04488040_1440 | SAMN04488040_3061 | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | Glutamate synthase (NADPH) large subunit. | 0.907 |
SFS67463.1 | ilvC | SAMN04488040_1440 | SAMN04488040_1689 | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.977 |
SFS67463.1 | ilvE | SAMN04488040_1440 | SAMN04488040_3037 | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | Branched chain amino acid aminotransferase apoenzyme; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. | 0.904 |
SFS67463.1 | leuA | SAMN04488040_1440 | SAMN04488040_2490 | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.921 |
SFS67463.1 | leuB | SAMN04488040_1440 | SAMN04488040_3007 | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.879 |
SFS67489.1 | SFS67463.1 | SAMN04488040_1442 | SAMN04488040_1440 | Fumarylacetoacetate (FAA) hydrolase family protein. | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | 0.839 |