REM1 protein (Saimiri boliviensis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

REM1

GTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (298 aa)

Predicted Functional Partners:

FRMPD2

0.736

CA10

0.720

MTOR

0.684

AKT1

0.669

ZHX2

0.658

EGFR

0.647

PIK3R1

0.633

GRB2

0.631

MAP2K1

0.627

NF1

0.622

Your Current Organism:

Saimiri boliviensis

NCBI taxonomy Id: 39432
Other names: Bolivian squirrel monkey, S. boliviensis boliviensis, Saimiri boliviensis boliviensis

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKT1	EGFR	ENSSBOP00000006552	ENSSBOP00000022799	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Receptor protein-tyrosine kinase.	0.916
AKT1	GRB2	ENSSBOP00000006552	ENSSBOP00000034988	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Growth factor receptor bound protein 2.	0.600
AKT1	MTOR	ENSSBOP00000006552	ENSSBOP00000036897	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	0.997
AKT1	NF1	ENSSBOP00000006552	ENSSBOP00000017589	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Neurofibromin 1.	0.604
AKT1	PIK3R1	ENSSBOP00000006552	ENSSBOP00000039285	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Phosphoinositide-3-kinase regulatory subunit 1.	0.992
AKT1	REM1	ENSSBOP00000006552	ENSSBOP00000001008	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	GTP-binding protein; Belongs to the small GTPase superfamily. RGK family.	0.669
AKT1	ZHX2	ENSSBOP00000006552	ENSSBOP00000001420	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Zinc fingers and homeoboxes 2.	0.472
CA10	REM1	ENSSBOP00000018894	ENSSBOP00000001008	Carbonic anhydrase 10; Belongs to the alpha-carbonic anhydrase family.	GTP-binding protein; Belongs to the small GTPase superfamily. RGK family.	0.720
EGFR	AKT1	ENSSBOP00000022799	ENSSBOP00000006552	Receptor protein-tyrosine kinase.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.916
EGFR	GRB2	ENSSBOP00000022799	ENSSBOP00000034988	Receptor protein-tyrosine kinase.	Growth factor receptor bound protein 2.	0.999
EGFR	MTOR	ENSSBOP00000022799	ENSSBOP00000036897	Receptor protein-tyrosine kinase.	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	0.681
EGFR	NF1	ENSSBOP00000022799	ENSSBOP00000017589	Receptor protein-tyrosine kinase.	Neurofibromin 1.	0.743
EGFR	PIK3R1	ENSSBOP00000022799	ENSSBOP00000039285	Receptor protein-tyrosine kinase.	Phosphoinositide-3-kinase regulatory subunit 1.	0.997
EGFR	REM1	ENSSBOP00000022799	ENSSBOP00000001008	Receptor protein-tyrosine kinase.	GTP-binding protein; Belongs to the small GTPase superfamily. RGK family.	0.647
FRMPD2	REM1	ENSSBOP00000036699	ENSSBOP00000001008	FERM and PDZ domain containing 2.	GTP-binding protein; Belongs to the small GTPase superfamily. RGK family.	0.736
GRB2	AKT1	ENSSBOP00000034988	ENSSBOP00000006552	Growth factor receptor bound protein 2.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.600
GRB2	EGFR	ENSSBOP00000034988	ENSSBOP00000022799	Growth factor receptor bound protein 2.	Receptor protein-tyrosine kinase.	0.999
GRB2	NF1	ENSSBOP00000034988	ENSSBOP00000017589	Growth factor receptor bound protein 2.	Neurofibromin 1.	0.472
GRB2	PIK3R1	ENSSBOP00000034988	ENSSBOP00000039285	Growth factor receptor bound protein 2.	Phosphoinositide-3-kinase regulatory subunit 1.	0.973
GRB2	REM1	ENSSBOP00000034988	ENSSBOP00000001008	Growth factor receptor bound protein 2.	GTP-binding protein; Belongs to the small GTPase superfamily. RGK family.	0.631