LONRF2 protein (Saimiri boliviensis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

LONRF2

LON peptidase N-terminal domain and ring finger 2. (511 aa)

Predicted Functional Partners:

CHST10

0.753

ADAD1

0.693

TP53BP1

0.605

SYPL2

0.599

TRIP12

0.596

ENSSBOP00000035224

0.586

RNF8

0.538

UBA52

0.518

ENSSBOP00000020952

0.518

BRCA1

0.503

Your Current Organism:

Saimiri boliviensis

NCBI taxonomy Id: 39432
Other names: Bolivian squirrel monkey, S. boliviensis boliviensis, Saimiri boliviensis boliviensis

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADAD1	CHST10	ENSSBOP00000021863	ENSSBOP00000009841	Adenosine deaminase domain containing 1.	Carbohydrate sulfotransferase.	0.693
ADAD1	LONRF2	ENSSBOP00000021863	ENSSBOP00000006234	Adenosine deaminase domain containing 1.	LON peptidase N-terminal domain and ring finger 2.	0.693
ADAD1	SYPL2	ENSSBOP00000021863	ENSSBOP00000009081	Adenosine deaminase domain containing 1.	Synaptophysin like 2.	0.495
BRCA1	ENSSBOP00000020952	ENSSBOP00000022189	ENSSBOP00000020952	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	Ubiquitin-like domain-containing protein.	0.516
BRCA1	ENSSBOP00000035224	ENSSBOP00000022189	ENSSBOP00000035224	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	Ubiquitin-like domain-containing protein.	0.641
BRCA1	LONRF2	ENSSBOP00000022189	ENSSBOP00000006234	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	LON peptidase N-terminal domain and ring finger 2.	0.503
BRCA1	RNF8	ENSSBOP00000022189	ENSSBOP00000024710	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...]	0.739
BRCA1	TP53BP1	ENSSBOP00000022189	ENSSBOP00000031184	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	Tumor protein p53 binding protein 1.	0.947
BRCA1	UBA52	ENSSBOP00000022189	ENSSBOP00000014554	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	Ubiquitin A-52 residue ribosomal protein fusion product 1.	0.516
CHST10	ADAD1	ENSSBOP00000009841	ENSSBOP00000021863	Carbohydrate sulfotransferase.	Adenosine deaminase domain containing 1.	0.693
CHST10	LONRF2	ENSSBOP00000009841	ENSSBOP00000006234	Carbohydrate sulfotransferase.	LON peptidase N-terminal domain and ring finger 2.	0.753
CHST10	SYPL2	ENSSBOP00000009841	ENSSBOP00000009081	Carbohydrate sulfotransferase.	Synaptophysin like 2.	0.601
ENSSBOP00000020952	BRCA1	ENSSBOP00000020952	ENSSBOP00000022189	Ubiquitin-like domain-containing protein.	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	0.516
ENSSBOP00000020952	ENSSBOP00000035224	ENSSBOP00000020952	ENSSBOP00000035224	Ubiquitin-like domain-containing protein.	Ubiquitin-like domain-containing protein.	0.963
ENSSBOP00000020952	LONRF2	ENSSBOP00000020952	ENSSBOP00000006234	Ubiquitin-like domain-containing protein.	LON peptidase N-terminal domain and ring finger 2.	0.518
ENSSBOP00000020952	RNF8	ENSSBOP00000020952	ENSSBOP00000024710	Ubiquitin-like domain-containing protein.	E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...]	0.783
ENSSBOP00000020952	TP53BP1	ENSSBOP00000020952	ENSSBOP00000031184	Ubiquitin-like domain-containing protein.	Tumor protein p53 binding protein 1.	0.783
ENSSBOP00000020952	TRIP12	ENSSBOP00000020952	ENSSBOP00000040471	Ubiquitin-like domain-containing protein.	Thyroid hormone receptor interactor 12.	0.922
ENSSBOP00000035224	BRCA1	ENSSBOP00000035224	ENSSBOP00000022189	Ubiquitin-like domain-containing protein.	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	0.641
ENSSBOP00000035224	ENSSBOP00000020952	ENSSBOP00000035224	ENSSBOP00000020952	Ubiquitin-like domain-containing protein.	Ubiquitin-like domain-containing protein.	0.963