STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CASP3Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family. (277 aa)    
Predicted Functional Partners:
XIAP
X-linked inhibitor of apoptosis.
   
 0.997
APAF1
Apoptotic peptidase activating factor 1.
    
 0.987
CASP8
Caspase 8; Belongs to the peptidase C14A family.
  
0.984
CASP9
Caspase 9; Belongs to the peptidase C14A family.
    
0.981
PARP1
Poly [ADP-ribose] polymerase.
   
 0.977
BIRC2
Baculoviral IAP repeat containing 2.
   
 0.977
DFFA
DNA fragmentation factor subunit alpha.
    
 0.975
BIRC3
Baculoviral IAP repeat containing 3.
   
 0.975
CASP10
Caspase 10; Belongs to the peptidase C14A family.
   
0.971
APPL1
Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1.
    
 0.969
Your Current Organism:
Saimiri boliviensis
NCBI taxonomy Id: 39432
Other names: Bolivian squirrel monkey, S. boliviensis boliviensis, Saimiri boliviensis boliviensis
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.