node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
GRB2 | KITLG | ENSSBOP00000034988 | ENSSBOP00000020445 | Growth factor receptor bound protein 2. | Kit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. | 0.502 |
GRB2 | PDGFA | ENSSBOP00000034988 | ENSSBOP00000019121 | Growth factor receptor bound protein 2. | Platelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. | 0.409 |
GRB2 | PDGFB | ENSSBOP00000034988 | ENSSBOP00000027945 | Growth factor receptor bound protein 2. | Platelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. | 0.421 |
GRB2 | PDGFRA | ENSSBOP00000034988 | ENSSBOP00000011970 | Growth factor receptor bound protein 2. | Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. | 0.971 |
GRB2 | PDGFRB | ENSSBOP00000034988 | ENSSBOP00000016719 | Growth factor receptor bound protein 2. | Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. | 0.987 |
GRB2 | PIK3CA | ENSSBOP00000034988 | ENSSBOP00000006220 | Growth factor receptor bound protein 2. | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. | 0.841 |
GRB2 | PIK3CB | ENSSBOP00000034988 | ENSSBOP00000007916 | Growth factor receptor bound protein 2. | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. | 0.610 |
GRB2 | PIK3R1 | ENSSBOP00000034988 | ENSSBOP00000039285 | Growth factor receptor bound protein 2. | Phosphoinositide-3-kinase regulatory subunit 1. | 0.972 |
GRB2 | PLCG1 | ENSSBOP00000034988 | ENSSBOP00000023812 | Growth factor receptor bound protein 2. | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. | 0.956 |
KITLG | GRB2 | ENSSBOP00000020445 | ENSSBOP00000034988 | Kit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. | Growth factor receptor bound protein 2. | 0.502 |
KITLG | PDGFRA | ENSSBOP00000020445 | ENSSBOP00000011970 | Kit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. | Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. | 0.963 |
KITLG | PDGFRB | ENSSBOP00000020445 | ENSSBOP00000016719 | Kit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. | Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. | 0.945 |
KITLG | PIK3CA | ENSSBOP00000020445 | ENSSBOP00000006220 | Kit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. | 0.552 |
KITLG | PIK3CB | ENSSBOP00000020445 | ENSSBOP00000007916 | Kit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. | 0.402 |
KITLG | PIK3R1 | ENSSBOP00000020445 | ENSSBOP00000039285 | Kit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. | Phosphoinositide-3-kinase regulatory subunit 1. | 0.440 |
PDGFA | GRB2 | ENSSBOP00000019121 | ENSSBOP00000034988 | Platelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. | Growth factor receptor bound protein 2. | 0.409 |
PDGFA | PDGFB | ENSSBOP00000019121 | ENSSBOP00000027945 | Platelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. | Platelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. | 0.987 |
PDGFA | PDGFD | ENSSBOP00000019121 | ENSSBOP00000021839 | Platelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. | Platelet derived growth factor D. | 0.978 |
PDGFA | PDGFRA | ENSSBOP00000019121 | ENSSBOP00000011970 | Platelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. | Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. | 0.994 |
PDGFA | PDGFRB | ENSSBOP00000019121 | ENSSBOP00000016719 | Platelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. | Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. | 0.986 |