node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BARD1 | BRCA1 | ENSSBOP00000016241 | ENSSBOP00000022189 | BRCA1 associated RING domain 1. | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | 0.999 |
BARD1 | BRIP1 | ENSSBOP00000016241 | ENSSBOP00000039240 | BRCA1 associated RING domain 1. | BRCA1 interacting protein C-terminal helicase 1. | 0.988 |
BARD1 | MLH1 | ENSSBOP00000016241 | ENSSBOP00000021808 | BRCA1 associated RING domain 1. | MutL homolog 1. | 0.634 |
BARD1 | MRE11 | ENSSBOP00000016241 | ENSSBOP00000003884 | BRCA1 associated RING domain 1. | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. | 0.990 |
BARD1 | NBN | ENSSBOP00000016241 | ENSSBOP00000022386 | BRCA1 associated RING domain 1. | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. | 0.989 |
BARD1 | PALB2 | ENSSBOP00000016241 | ENSSBOP00000032506 | BRCA1 associated RING domain 1. | Partner and localizer of BRCA2. | 0.946 |
BARD1 | PMS2 | ENSSBOP00000016241 | ENSSBOP00000024493 | BRCA1 associated RING domain 1. | PMS1 homolog 2, mismatch repair system component. | 0.423 |
BARD1 | SLF1 | ENSSBOP00000016241 | ENSSBOP00000018594 | BRCA1 associated RING domain 1. | SMC5-SMC6 complex localization factor 1. | 0.994 |
BARD1 | TOPBP1 | ENSSBOP00000016241 | ENSSBOP00000014527 | BRCA1 associated RING domain 1. | DNA topoisomerase II binding protein 1. | 0.987 |
BARD1 | WRN | ENSSBOP00000016241 | ENSSBOP00000021357 | BRCA1 associated RING domain 1. | WRN RecQ like helicase. | 0.985 |
BRCA1 | BARD1 | ENSSBOP00000022189 | ENSSBOP00000016241 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | BRCA1 associated RING domain 1. | 0.999 |
BRCA1 | BRIP1 | ENSSBOP00000022189 | ENSSBOP00000039240 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | BRCA1 interacting protein C-terminal helicase 1. | 0.999 |
BRCA1 | MLH1 | ENSSBOP00000022189 | ENSSBOP00000021808 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | MutL homolog 1. | 0.902 |
BRCA1 | MRE11 | ENSSBOP00000022189 | ENSSBOP00000003884 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. | 0.990 |
BRCA1 | NBN | ENSSBOP00000022189 | ENSSBOP00000022386 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. | 0.954 |
BRCA1 | PALB2 | ENSSBOP00000022189 | ENSSBOP00000032506 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | Partner and localizer of BRCA2. | 0.999 |
BRCA1 | PMS2 | ENSSBOP00000022189 | ENSSBOP00000024493 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | PMS1 homolog 2, mismatch repair system component. | 0.714 |
BRCA1 | SLF1 | ENSSBOP00000022189 | ENSSBOP00000018594 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | SMC5-SMC6 complex localization factor 1. | 0.913 |
BRCA1 | TOPBP1 | ENSSBOP00000022189 | ENSSBOP00000014527 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | DNA topoisomerase II binding protein 1. | 0.990 |
BRCA1 | WRN | ENSSBOP00000022189 | ENSSBOP00000021357 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | WRN RecQ like helicase. | 0.979 |