Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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tilStRNA(Ile)-lysidine synthetase; Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. Belongs to the tRNA(Ile)-lysidine synthase family. (481 aa)    
Predicted Functional Partners:
Ccel_0084
TIGRFAM: hypoxanthine phosphoribosyltransferase; PFAM: phosphoribosyltransferase; KEGG: cth:Cthe_2254 hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family.
  
 0.976
Ccel_0082
Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily.
  
    0.849
pth
peptidyl-tRNA hydrolase; The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. Belongs to the PTH family.
 
  
 0.808
rplI
Ribosomal protein L9; Binds to the 23S rRNA.
  
  
 0.760
mfd
Transcription-repair coupling factor; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily.
 
    0.745
ftsH
ATP-dependent metalloprotease FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; In the central section; belongs to the AAA ATPase family.
     
 0.706
Ccel_0080
Phosphoesterase RecJ domain protein; Has phosphodiesterase (PDE) activity against cyclic-di-AMP (c-di-AMP); Belongs to the GdpP/PdeA phosphodiesterase family.
 
     0.690
tadA
CMP/dCMP deaminase zinc-binding; Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2); Belongs to the cytidine and deoxycytidylate deaminase family.
 
  
 0.658
Ccel_0800
PFAM: peptidase M22 glycoprotease; KEGG: cth:Cthe_1775 peptidase M22, glycoprotease.
 
   
 0.632
truA
tRNA pseudouridine synthase A; Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
  
  
 0.629
Your Current Organism:
Ruminiclostridium cellulolyticum
NCBI taxonomy Id: 394503
Other names: Clostridium cellulolyticum H10, R. cellulolyticum H10, Ruminiclostridium cellulolyticum H10
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